2010 Fiscal Year Final Research Report
Creation and Pharmaceutical Development of Intelligent Zinc Fingers Based on Genomic Chemistry
| Project/Area Number |
20390037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
SUGIURA Yukio Doshisha Women's College of Liberal Arts, 薬学部, 特任教授 (40025698)
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| Co-Investigator(Kenkyū-buntansha) |
NEGI Shigeru 同志社女子大学, 薬学部, 助教 (50378866)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 亜鉛フィンガー / 転写因子 / DNA結合 / タンパク質デザイン / マルチフィンガー / 人工転写因子 / 遺伝子制御 / Zif268 |
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| Research Abstract |
By re-design of native zinc finger proteins, the following artificial proteins were created : (1) restriction enzyme-like molecule possessing DNA hydrolytic ability, (2) genome-regulating molecule with long DNA base recognition, and (3) metal-responsive artificial transcriptional switcher. The pharmaceutical application of these new proteins were investigated in this work.
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