2010 Fiscal Year Final Research Report
Functional morphologic study of the peripheral cholinergic nervous system in human.
| Project/Area Number |
20390051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
KIMURA Hiroshi Shiga University of Medical Science, 名誉教授 (40079736)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 末梢型コリンアセチル基転移酵素 / アセチルコリン / 腸管神経系 / アミノ酸配列 / 抗体作成 / 免疫組織化学 / 神経伝達物質 |
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| Research Abstract |
We have previously demonstrated that the neurotransmitter acetylcholine is synthesized by two enzymes, cChAT and pChAT. The pChAT occurs not only in peripheral cholinergic neurons but also in neuronal crest derived neurons (primary sensory, postganglionic sympathetic and intramural enteric neurons) of experimental animals. The present study aims at examining whether pChAT is also present in humans. Using protein purification and antibody production methods, we have firstly succeeded to visualize neurons containing human pChAT.
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