2010 Fiscal Year Final Research Report
Role of nerve growth factor (NGF) in muscular pain
| Project/Area Number |
20390063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
MIZUMURA Kazue Nagoya University, 環境医学研究所, 教授 (00109349)
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| Co-Investigator(Renkei-kenkyūsha) |
KATANOSAKA Kimiaki 名古屋大学, 環境医学研究所, 助教 (50335006)
KOZAKI Yasuko 金城学院大学, 薬学部, 准教授 (20126882)
TAGUCHI Toru 名古屋大学, 環境医学研究所, 助教 (90464156)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 筋性疼痛 / 神経成長因子 / 遅発性筋痛 / ブラジキニン |
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| Research Abstract |
To clarify the peripheral mechanism of muscular mechanical hyperalgesia, we analyzed roles of nerve growth factor (NGF) produced in the muscle in a few muscular pain models. We demonstrated that delayed onset muscle soreness was a result of sensitization of thin-fiber receptors by NGF that was up-regulated in the muscle after activation of B2 bradykinin receptors during exercise. We also demonstrated that NGF was not involved in muscular mechanical hyperalgesia in the repeated cold stress model, whereas it was involved in the spinal nerve ligation/cut model.
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