Identification of Genes for Cognition and Their Functional Analysis

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: Osaka University
• Principal Investigator: TODA Tatsushi Osaka University, 大学院・医学研究科, 教授 (30262025)
• Project Period (FY): 2008 – 2010
• Keywords: 分子遺伝学

Research Abstract

By microarray analysis, we detected copy number abnormality in MR patients. We also found that inflammatory cytokines had different expression between IQ-discordant monozygotic twins.

Research Products

• [Journal Article] Genetic and clinical analysis in a Chinese parkinsonism- predominant spinocerebellar ataxia type 2 family. (2011)
  • Author(s): Sun H, Satake W, Zhang C, Nagai Y, Tian Y, Fu S, Yu J, Qian Y, Qian Y, Chu J, Toda T
  • Journal Title: J Hum Genet 56(4) Pages: 330-334
  • Peer Reviewed
• [Journal Article] Defective glycosylation of α-dystroglycan contributes to podocyte flattening. (2011)
  • Author(s): Kojima K, Nosaka H, Kishimoto Y, Nishiyama Y, Fukuda S, Shimada M, Kodaka K, Saito F, Matsumura K, Shimizu T, Toda T, Takeda S, Kawachi H, Uchida S.
  • Journal Title: Kidney Int 79 Pages: 311-316
  • Peer Reviewed
• [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. (2011)
  • Author(s): Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T.
  • Journal Title: Proc Natl Acad Sci U S A 108 Pages: 3701-3706
  • Peer Reviewed
• [Journal Article] Post- translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. (2010)
  • Author(s): Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T
  • Journal Title: J Biol Chem 285 Pages: 31208-31216
  • Peer Reviewed
• [Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism : screening strategy in parkinsonism. (2009)
  • Author(s): Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N.
  • Journal Title: Neurosci Lett 455 Pages: 159-161
  • Peer Reviewed
• [Journal Article] Fukutin gene retrotransposal insertion in a non-Japanese Fukuyama congenital muscular dystrophy (FCMD) patient. (2009)
  • Author(s): Xiong H, Wang S, Kobayashi K, Jiang Y, Wang J, Chang X, Yuan Y, Liu J, Toda T, Fukuyama Y, Wu X.
  • Journal Title: Am J Med Genet 149A Pages: 2403-2408
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (2009)
  • Author(s): Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
  • Journal Title: Nature Genet 41 Pages: 1303-1307
  • Peer Reviewed
• [Journal Article] Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. (2009)
  • Author(s): Sidransky E, Nalls MA, Aasly JO, ...Toda T, et al.
  • Journal Title: N Engl J Med 361 Pages: 1651-1661
  • Peer Reviewed
• [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice. (2009)
  • Author(s): Popiel HA, Nagai Y, Fujikake N, Toda T
  • Journal Title: Neurosci Lett 449 Pages: 87-92
  • Peer Reviewed
• [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease. (2009)
  • Author(s): Mitsui J, Mizuta I, Toyoda A, Ashida R, Takahashi Y, Goto J, Fukuda Y, Date H, Iwata A, Yamamoto M, Hattori N, Murata M, Toda T, Tsuji S.
  • Journal Title: Arch Neurol 66 Pages: 571-576
  • Peer Reviewed
• [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligence tests. (2009)
  • Author(s): Shikishima C, Hiraishi K, Yamagata S, Sugimoto Y, Takemura R, Ozaki K, Okada M, Toda T, Ando J.
  • Journal Title: Intelligence 37 Pages: 256-267
  • Peer Reviewed
• [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy. (2009)
  • Author(s): Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T
  • Journal Title: Hum Mol Genet 18 Pages: 621-631
  • Peer Reviewed
• [Journal Article] Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones. (2008)
  • Author(s): Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T
  • Journal Title: J Biol Chem 283 Pages: 26188-26197
  • Peer Reviewed
• [Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. (2008)
  • Author(s): Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.
  • Journal Title: Nature Neurosci 11 Pages: 923-931
  • Peer Reviewed
• [Journal Article] Calbindin 1, fibroblast growth factor 20, and ?-synuclein in Parkinson's disease. (2008)
  • Author(s): Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T
  • Journal Title: Hum Genet 124 Pages: 89-94
  • Peer Reviewed
• [Journal Article] 認知と遺伝子 (2008)
  • Author(s): 小林千浩, 戸田達史
  • Journal Title: Cognition and Dementia 7 Pages: 35-43
• [Presentation] 認知能力の差が顕著な-卵性双生児のDNAメチル化解析 (2010)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、瀬々潤、菅原裕子、岩本和也、加藤忠史、安藤寿康、戸田達史
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 20101200
• [Presentation] Genome-wide gene expression and DNA methylation analyses of significantly discordant monozygotic twins for cognitive ability. (2010)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、瀬々潤、菅原裕子、岩本和也、加藤忠史、安藤寿康、戸田達史
  • Organizer: American Society of Human Genetics 60th Annual Meeting.
  • Place of Presentation: Washington D.C., 米国
  • Year and Date: 20101100
• [Presentation] 認知能力の差が顕著な-卵性双生児の網羅的遺伝子発現・DNAメチル化解析. (2010)
  • Author(s): 小林千浩
  • Organizer: 日本パーソナリティ心理学会第19回大会(招待講演)
  • Place of Presentation: 慶應義塾大学三田キャンパス
  • Year and Date: 20101000
• [Presentation] 認知能力の差が顕著な-卵性双生児の分子遺伝学的解析 (2010)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、瀬々潤、菅原裕子、岩本和也、加藤忠史、安藤寿康、戸田達史
  • Organizer: 日本人類遺伝学会第55回大会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 20101000
• [Presentation] Genomic analysis of monozygotic twins discordant for cognitive ability (2009)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、安藤寿康、戸田達史
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20091200
• [Presentation] Expression analysis of monozygotic twins discordant for cognitive ability. (2009)
  • Author(s): 古川真理、小林千浩、游智傑、瀬々潤、敷島千鶴、安藤寿康、戸田達史
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20091200
• [Presentation] Genetic Analysis of Monozygotic Twins Discordant for Cognitive Abilities. (2009)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、安藤寿康、戸田達史
  • Organizer: 第59回米国人類遺伝学会年会
  • Place of Presentation: Hawaii, 米国
  • Year and Date: 20091000
• [Presentation] 精神発達遅滞における500K SNPチップを用いたコピー数変化領域のスクリーニングと原因遺伝子の同定 (2008)
  • Author(s): 小林千浩、牟禮岳男、金城薫、千代延友裕、西村陽、平井清、森本昌史、松尾雅文、稲澤譲治、戸田達史
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 20081200
• [Presentation] Copy number variation screening with the 500k SNP array in patients with mental retardation. (2008)
  • Author(s): 小林千浩、牟禮岳男、金城薫、千代延友裕、西村陽、平井清、森本昌史、松尾雅文、稲澤譲治、戸田達史
  • Organizer: The American Society of Human Genetics. 58th Annual Meeting.
  • Place of Presentation: Philadelphia, 米国
  • Year and Date: 20081100
• [Presentation] 精神発達遅滞児(者)における500KSNPチップを用いたコピー数変化領域のスクリーニングと原因遺伝子の同定 (2008)
  • Author(s): 牟禮岳男、小林千浩、金城薫、千代延友裕、西村陽、平井清、森本昌史、松尾雅文、稲澤譲治、戸田達史
  • Organizer: 日本人類遺伝学会第53回大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 20080900
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/shinkei/index.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/clgene/