Role of PDGF signal in normal and injured brain.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390108
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: University of Toyama
• Principal Investigator: SASAHARA Masakiyo University of Toyama, 大学院・医学薬学研究部(医学), 教授 (20154015)
• Project Period (FY): 2008 – 2011
• Keywords: 疾患モデル動物

Research Abstract

本研究は、脳に発現する血小板由来増殖因子(PDGF)が、高次脳機能の維持や、損傷脳の再生にどのように関与するのかを解明することを目的にしている。このために、独自に開発したPDGF受容体の条件的ノックアウト(KO)マウスを用いた、In vivo, In vitroの解析を行うことが特徴である。

Research Products

• [Journal Article] Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-β Gene Knockout Mice. (2011)
  • Author(s): Nguyen PT, Nakamura T, HoriE, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
  • Journal Title: PLoS One. 6(3) Pages: e18004
  • Peer Reviewed
• [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus. (2011)
  • Author(s): Nakagawa T, Izumino K, Ishii Y, Oya T, Hamashima T, Jie S, Ishizawa S, Tomoda F, Fujimori T, Nabeshima Y, Inoue H, Sasahara M.
  • Journal Title: Nephrol Dial Transplant. 26(2) Pages: 458-68
  • Peer Reviewed
• [Journal Article] Involvement of platelet-derived growth factor-BB and its receptor-beta in hypoxia-induced depression of excitatory synaptic transmission in the nucleus tractus solitarius of mice. (2010)
  • Author(s): Ohi Y, Ishii Y, Sasahara M, Haji A.
  • Journal Title: J Pharmacol Sci. 112(4) Pages: 477-481
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved. (2010)
  • Author(s): Zheng L, Ishii Y, Tokunaga A, Hamashima T, Shen J, Zhao QL, Ishizawa S, Fujimori T, Nabeshima Y, Mori H, Kondo T, Sasahara M.
  • Journal Title: J Neurosci Res. 88(6) Pages: 1273-1284
  • Peer Reviewed
• [Journal Article] Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves. (2009)
  • Author(s): Yamazaki T, Sabit H, Oya T, Ishii Y, Hamashima T, Tokunaga A, Ishizawa S, Jie S, Kurashige Y, Matsushima T, Furuta I, Noguchi M, Sasahara M.
  • Journal Title: J Peripher Nerv Syst. 14(3) Pages: 165-176
  • Peer Reviewed
• [Journal Article] Hypoxic ventilatory response in platelet-derived growth factor receptor-beta-knockout mice. (2009)
  • Author(s): Tsunekawa S, Ohi Y, Ishii Y, Sasahara M, Haji A.
  • Journal Title: J Pharmacol Sci. 110(3) Pages: 270-275
  • Peer Reviewed
• [Journal Article] PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. (2008)
  • Author(s): Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M.
  • Journal Title: J Bone Miner Res. 23(9) Pages: 1519-1528
  • Peer Reviewed
• [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice. (2008)
  • Author(s): Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M, Funa K.
  • Journal Title: Mol Cell Neurosci. 37(3) Pages: 507-518
  • Peer Reviewed
• [Presentation] The Involvement of PDGFR-β in the Maturation of Blood Vessel after Focal Cerebral Ischemia. (2010)
  • Author(s): Shen J., Ishii Y., Xu G., Hamashima T., Matsushima T., Yamamoto S., Takatsuru Y., Nabekura J., Sasahara M.
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society(Neuro 2010)(Res., 68(Suppl.1): e97, 2010)
  • Place of Presentation: Kobe.Neurosci.
  • Year and Date: 20100902-20100904
• [Presentation] PDGFR-β deletion improves diabetic nephropathy in CaM Kinase II α(Thr286Asp) Transgenic Mice. (2010)
  • Author(s): Suzuki H., Usui I., Kato I., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Urakaze M., Sasahara M., Takasawa S., Okamoto H., Kobayashi M., Tobe K.
  • Organizer: American Diabetes Association (ADA) 70th Scientific Sessions(59(Suppl.1): A1, 2010)
  • Place of Presentation: Orlando, USA.Diabetes
  • Year and Date: 20100625-20100629
• [Presentation] Neurovascular signaling of PDGF receptor beta protects CNS from insults, a study using conditional knockout mouse. (2010)
  • Author(s): Sasahara M., Ishii Y., Shen J., Hamashima T.
  • Organizer: BIT's 1st Annual World Congress of NeuroTalk-2010
  • Place of Presentation: Singapore.(Invited lecture)
  • Year and Date: 20100625-20100628
• [Presentation] The Role for PDGFR-s as a Positive Regulator of Vessels Maturation after Focal Cerebral Ischemia in Mice. (2010)
  • Author(s): Shen J., Ishii Y., Hamashima T., Sasahara M.
  • Organizer: BIT's 1st Annual World Congress of NeuroTalk-2010.
  • Place of Presentation: Singapore.
  • Year and Date: 20100625-20100628