Molecular basis of immune evasion of malaria parasites

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390121
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Kyushu University
• Principal Investigator: HISAEDA Hajime Kyushu University, 大学院・医学系研究科, 教授 (50243689)
• Project Period (FY): 2008 – 2010
• Keywords: マラリア / 制御性T細胞 / TLR9

Research Abstract

Mechanisms underlying immune evasion due to activation of regulatory T cells during blood-stage malaria have been carefully analyzed. Stimulation of dendritic cells with parasitized red blood cells through TLR9 resulted in activation of regulatory T cells. Furthermore, mice deficient in TLR9 were partially resistant to lethal malaria because of a failure of activating regulatory T cells. It was suggested that hemozoin, malaria pigment, is involved in activation of regulatory T cells as TLR9 ligand. We also analyzed "suppressed" protective immunity to malaria, and found protective roles of CD8 T cells previously supposed to be unlike to contribute to protection to blood-stage malaria.

Research Products

• [Journal Article] A critical role for phagocytosis in resistance to malaria in iron-deficient mice. (2011)
  • Author(s): Moriya-Matsuzaki C, Tu L, Ishida H, Imai T, Suzue K, Hirai M, Tetsutani K, Hamano S, Shimokawa C, Hisaeda H
  • Journal Title: Eur.J.Immunol. (in press)
  • Peer Reviewed
• [Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17. (2010)
  • Author(s): Ishida H, Matsuzaki-Moriya C, Imai T, Yanagisawa K, Nojima Y, Suzue K, Hirai M, Iwakura Y, Yoshimura A, Hamano S, Shimokawa C, Hisaeda H
  • Journal Title: Biochem. Biophys. Res.Commun. 402 Pages: 790-795
  • Peer Reviewed
• [Journal Article] Involvement of CD8^+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain. (2010)
  • Author(s): Imai T, Shen J, Chou B, Duan X, Tu L, Tetsutani K, Moriya C, Ishida H, Hamano S, Shimokawa C, Hisaeda H, Himeno K
  • Journal Title: Eur.J.Immunol. 40 Pages: 1053-1061
  • Peer Reviewed
• [Journal Article] Critical role for immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection. (2009)
  • Author(s): Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H, Himeno K
  • Journal Title: Eur.J.Immunol. 39 Pages: 3385-3394
  • Peer Reviewed
• [Journal Article] Concurrent infection with Heligmosomoides polygyrus suppresses anti-Plasmodium yoelii protection partially by induction of CD4^+CD25^+Foxp3^+ Treg in mice. (2009)
  • Author(s): Tetsutani K, Ishiwata K, Ishida H, Tu L, Torii M, Hamano S, Himeno K, Hisaeda H
  • Journal Title: Eur.J.Immunol. 39 Pages: 2822-2830
  • Peer Reviewed
• [Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. (2008)
  • Author(s): Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
  • Journal Title: J Immunol 180 Pages: 2496-2503
  • Peer Reviewed
• [Presentation] Protective roles of IL-23 against murine malaria. (2010)
  • Author(s): Ishida H, Hisaeda H
  • Organizer: Cell炎症の国際シンポジウム
  • Place of Presentation: ヒルトンホテル(リスボン、ポルトガル)
  • Year and Date: 2010-09-28
• [Presentation] Training Course, Parasitology. (2010)
  • Author(s): Hisaeda H
  • Organizer: 第10回淡路国際感染症フォーラム
  • Place of Presentation: 淡路国際会議場(兵庫県)
  • Year and Date: 2010-09-08
• [Presentation] Protection exerted by CD8+ T cell sagainst murine blood-stage malaria. (2010)
  • Author(s): Hisaeda H
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-08-21
• [Presentation] Influence of nematode infection on anti-malaria immunity in mice. (2010)
  • Author(s): Tetsutani K, Hisaeda H
  • Organizer: 第44回日米医学協力プログラム
  • Place of Presentation: ヒルトンホテル(サンディエゴ、合衆国)
  • Year and Date: 2010-01-10
• [Presentation] Malaria parasites require Toll-like receptor 9 signaling for immune evasion by acrivating regulatory Tcells. (2008)
  • Author(s): Hisaeda H
  • Organizer: キーストーンシンポジウム
  • Place of Presentation: Alpbach Congress Centrum (Alpbach, Austria)
  • Year and Date: 2008-06-10
• [Remarks]
  • URL: http://www.med.gunma-u.ac.jp/parasitology/