2010 Fiscal Year Final Research Report
A novel tuberculosis vaccine strategy to regulate the latent infection and resuscitation of Mycobacterium tuberculosis
| Project/Area Number |
20390125
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
KOIDE Yukio Hamamatsu University School of Medicine, 医学部, 理事 (30126809)
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
TSUJIMURA Kunio 浜松医科大学, 医学部, 准教授 (10227407)
UCHIJIMA Masato 浜松医科大学, 医学部, 助教 (20252174)
SETO Shintaro 浜松医科大学, 医学部, 助教 (50383203)
CHIDA Kingo 浜松医科大学, 医学部, 准教授 (40197611)
SUDA Takafumi 浜松医科大学, 医学部, 助教 (30291397)
KATO Hideki 浜松医科大学, 医学部, 准教授 (30142053)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ワクチン / 結核菌 / 潜伏期 / 再燃 |
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| Research Abstract |
Immunogenicity against latency-associated proteins of Mycobacterium tuberculosis (DosR and resuscitation promoting factor (Rpf) proteins) was investigated using C57BL/6 and BALB/c mice. Seven and three antigens were found to induce T cell responses and antibody production in both strains, respectively. Oligomannose-coated liposomes and chimeric-molecule vaccines utilizing fusion proteins of a tuberculosis antigen and heat shock protein 70 or a chemokine (MIP-1α) were established as new technologies to facilitate the antigen uptake by dendritic cells.
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Research Products
(56 results)
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[Journal Article] HapMap scanning of novel human minor histocompatibility antigens.2009
Author(s)
Kamei M, Nannya Y, Torikai H, Kawase T, Taura K, Inamoto Y, Takahashi T, Yazaki M, Morishima S, Tsujimura K, Miyamura K, Ito T, Togari H, Riddell SR, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y
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Journal Title
Blood 113
Pages: 5041-5048
Peer Reviewed
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[Journal Article] Identification of an HLA-A*0201- restricted T-cell epitope on the MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis, by MPT51 overlapping peptide screening.2008
Author(s)
Aoshi T,Nagata T, Suzuki M, Uchijima M, Hashimoto D, Rafiei A, Suda T, Chida K, Koide Y
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Journal Title
Infect Immun 76
Pages: 1565-1571
Peer Reviewed
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[Journal Article] Identification of a human leukocyte antigen-A24-restricted T-cell epitope derived from interleukin-13 receptor α2 chain, a glioma-associated antigen.2008
Author(s)
Shimato S, Natsume A, Wakabayashi T, Tsujimura K, Nakahara N, Ishii J, Ito M, Akatsuka Y, Kuzushima K, Yoshida J
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Journal Title
J Neurosurg 109
Pages: 117-122
Peer Reviewed
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[Journal Article] The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma.2008
Author(s)
Natsume A, Wakabayashi T, Tsujimura K, Shimato S, Ito M, Kuzushima K, Kondo Y, Sekido Y, Kawatsura H, Narita Y, Yoshida J
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Journal Title
Int J Cancer 122
Pages: 2542-2553
Peer Reviewed
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[Journal Article] Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA.2008
Author(s)
Kawase T, Nanya Y, Torikai H, Yamamoto G, Onizuka M, Morishima S, Tsujimura K, Miyamura K, Kodera Y, Morishima Y, Takahashi T, Kuzushima K, Ogawa S, Akatsuka Y
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Journal Title
Blood 111
Pages: 3286-3294
Peer Reviewed
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[Journal Article] Effective induction of anti-tumor immune responses with oligomannose-coated liposome targeting to intraperitoneal phagocytic cells.2008
Author(s)
Ikehara Y, Shiuchi N, Kabata-Ikehara S, Nakanishi H, Yokoyama N, Takagi H, Nagata T, Koide Y, Kuzushima K, Takahashi T, Tsujimura K, Kojima N.
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Journal Title
Cancer Lett 260
Pages: 137-145
Peer Reviewed
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