2010 Fiscal Year Final Research Report
Identification and functional analysis of factors related to human herpesvirus pathogenesis
| Project/Area Number |
20390138
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kobe University |
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Principal Investigator |
MORI Yasuko Kobe University, 大学院・医学研究科, 教授 (50343257)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Shigefumi 医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー (50311759)
TAKEMOTO Masaya 医薬基盤研究所, 基盤研究部, 研究員 (60379237)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子発現 / 細胞向性 / ウイルス感染 / 病原性 |
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| Research Abstract |
HHV-6 is T lympho-tropic virus and causes several diseases by reactivation, but it is still unknown regarding the pathogenesis. Here we successfully established the construction system of HHV-6 recombinant virus that had not been established yet. We found that envelope glycoprotein gQ1 that is HHV-6 specific gene is essential for virus growth. Moreover, we found that HHV-6 is captured and transmitted to T cells by DC, and can replicate in T cells completely.
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