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2010 Fiscal Year Final Research Report

Neuroscientific studies on the effect of moxibustion on chronic diseases

Research Project

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Project/Area Number 20390200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionFujita Health University

Principal Investigator

USUDA Nobuteru  Fujita Health University, 医学部, 教授 (30135123)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Satoshi  藤田保健衛生大学, 医学部, 教授 (50340229)
NAGATSU Toshiharu  藤田保健衛生大学, 医学部, 名誉教授 (40064802)
MURAKAMI Kazuo  国際科学振興財団, バイオ研究所, 研究所長 (70110517)
NAKAI Sachiko  藤田保健衛生大学, 医学部, 研究員 (30257836)
WATARI Nakazou  藤田保健衛生大学, 医学部, 客員教授 (40079976)
NAGATSU Ikuko  藤田保健衛生大学, 医学部, 名誉教授 (80084573)
NAKAHARA Daiichirou  浜松医科大学, 医学部, 教授 (80128389)
HIGUCHI Susumu  藤田保健衛生大学, 医学部, 客員教授 (40156576)
TAKAHASHI Hisahide  藤田保健衛生大学, 名誉教授 (80084606)
HATA Toshimichi  同志社大学, 心理学部, 准教授 (50399044)
HAYASHI Takashi  国際科学振興財団, バイオ研究所, 研究員 (80399328)
FUKASAWA Motoaki  藤田保健衛生大学, 医学部, 助教 (70387728)
ATSUZAWA Kimie  藤田保健衛生大学, 医学部, 助教 (60387727)
MATSUZAWA Ayami  藤田保健衛生大学, 医学部, 客員講師 (90273078)
YAMAZAKI Masao  藤田保健衛生大学, 医療科学部, 教授 (10192395)
NAGAOKA Toshiharu  藤田保健衛生大学, 医療科学部, 教授 (20021420)
OKAWARA Takeshi  藤田保健衛生大学, 医学部, 助教 (20469034)
Co-Investigator(Renkei-kenkyūsha) SETOU Mitsutoshi  大学共同利用機関法人自然科学研究機構(共通施設), 統合バイオサイエンスセンター, 准教授 (20302664)
OOSUKA Kouzi  愛知医科大学, 医学部, 准教授 (40378013)
KANEKO Rina  藤田保健衛生大学, 医学部, 助教 (70367697)
Project Period (FY) 2008 – 2010
Keywords東洋医学 / 施灸の脳科学
Research Abstract

Subjective evidence of the brain reactions for moxibustion was attempted. Moxibustion treatment was done on rats, and measurements of brain functions based on neurotransmitter secretion by microdialysis; electrophysiological changes including EEG ; and gene expression analyses by DNA microarray, were performed. As all the reaction measured was very weak, high S/N ratio was required. Dopamine secretion, elevated gene expression, the elevation of body temperature, changes of hippocampal θwave in EEG, were shown in the experiments. As these are considered to affect brain functions including emotion, memory, etc, moxibustion may have possible curative effects on chronic diseases.

  • Research Products

    (24 results)

All 2011 2010 2009 2008

All Journal Article (19 results) (of which Peer Reviewed: 18 results) Presentation (5 results)

  • [Journal Article] Activation of PI3 kinase/Akt signaling in chronic subdural hematoma outer membranes.2011

    • Author(s)
      Funai M, Osuka K, Usuda N, Atsuzawa K, Inukai T, Yasuda M, Watanabe Y, Takayasu M.
    • Journal Title

      J Neurotrauma. 28(in press)

  • [Journal Article] Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.2011

    • Author(s)
      Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T, Ota A.
    • Journal Title

      Biochem Biophys Res Commun. 407(in press)

    • Peer Reviewed
  • [Journal Article] Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice.2011

    • Author(s)
      Nakamura M, Gao S, Okamura H, Nakahara D.
    • Journal Title

      Psychopharmacology. 213

      Pages: 119-129

    • Peer Reviewed
  • [Journal Article] Evaluation of blood purification and bortezomib plus dexamethasone therapy for the treatment of acute renal failure due to myeloma cast nephropathy.2010

    • Author(s)
      Hasegawa M, Sugiyama S, Yuzawa Y., 他
    • Journal Title

      Ther Apher Dial. 14

      Pages: 451-456

    • Peer Reviewed
  • [Journal Article] Neurogenesis in the dentate gyrus of the rat hippocampus enhanced by tickling stimulation with positive emotion.2010

    • Author(s)
      Yamamuro T, Senzaki K, Iwamoto S, Nakagawa Y, Hayashi T, Hori M, Sakamoto S, Murakami K, Shiga T, Urayama O.
    • Journal Title

      Neurosci Res. 68

      Pages: 285-289

    • Peer Reviewed
  • [Journal Article] Changes in the serum bone metabolism markers of elderly alcoholics during abstinence.2010

    • Author(s)
      Matsui T, Yokoyama A, Matsushita S, Mori S, Arai H, Higuchi S, Maruyama K.
    • Journal Title

      J Am Geriatr Soc. 58

      Pages: 984-986

    • Peer Reviewed
  • [Journal Article] Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage.2010

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, Takayasu M.
    • Journal Title

      Brain Res. 1332

      Pages: 12-19

    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of mitochondrial fatty acid beta-oxidation enzymes in rat testis.2010

    • Author(s)
      Fukasawa M, Atsuzawa K, Mizutani K, Nakazawa (Matsuzawa) A, Usuda N.
    • Journal Title

      J Histochem Cytochem. 58

      Pages: 195-206

    • Peer Reviewed
  • [Journal Article] Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP- and ethanol-induced brain injury.2010

    • Author(s)
      Sawada H, Suzuki H, Nagatsu T, Sawada M.
    • Journal Title

      Neurodegener Dis. 7

      Pages: 64-67

    • Peer Reviewed
  • [Journal Article] Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers.2010

    • Author(s)
      Matsui T, Higuchi S, Maruyama K., 他
    • Journal Title

      Alcohol Clin Exp Res. 34

      Pages: 869-875

    • Peer Reviewed
  • [Journal Article] Novel therapeutic approach for Alzheimer's disease by removing amyloid beta protein from the brain with an extracorporeal removal system.2010

    • Author(s)
      Kawaguchi K, Kitaguchi N, Nakai S, Murakami K, Asakura K, Mutoh T, Fujita Y, Sugiyama S.
    • Journal Title

      J Artif Organs. 13

      Pages: 31-37

    • Peer Reviewed
  • [Journal Article] The effects of laughter on post-prandial glucose levels and gene expression in type 2 diabetic patients.2009

    • Author(s)
      Hayashi T, Murakami K.
    • Journal Title

      Life Sci. 85

      Pages: 185-187

    • Peer Reviewed
  • [Journal Article] Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.2009

    • Author(s)
      Takei N, Higuchi S, Kuwano R., 他
    • Journal Title

      Genomics. 93

      Pages: 441-448

    • Peer Reviewed
  • [Journal Article] Decrease in the prevalence of adolescent alcohol use and its possible causes in Japan : periodical nationwide cross-sectional surveys.2009

    • Author(s)
      Osaki Y, Tanihata T, Ohida T, Kanda H, Suzuki K, Higuchi S, Kaneita Y, Minowa M, Hayashi K.
    • Journal Title

      Alcohol Clin Exp Res. 33

      Pages: 247-254

    • Peer Reviewed
  • [Journal Article] Assessing multidimensional cognitions of drinking among alcohol-dependent patients : development and validation of a drinking-related cognitions scale (DRCS).2009

    • Author(s)
      Sawayama T, Yoneda J, Tanaka K, Shirakawa N, Sawayama E, Higuchi S, Miyaoka H.
    • Journal Title

      Addict Behav. 34

      Pages: 82-85

    • Peer Reviewed
  • [Journal Article] Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy.2008

    • Author(s)
      Matsushita S, Miyakawa T, Maesato H, Matsui T, Yokoyama A, Arai H, Higuchi S, Kashima H.
    • Journal Title

      Alcohol Clin Exp Res. 32

      Pages: 1091-1095

    • Peer Reviewed
  • [Journal Article] The HLA-DRB1^*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease.2008

    • Author(s)
      Kitagawa W, Imai H, Komatsuda A, Maki N, Wakui H, Hiki Y, Sugiyama S.
    • Journal Title

      Nephrol Dial Transplant. 23

      Pages: 3126-3129

    • Peer Reviewed
  • [Journal Article] Peripheral lipopolysaccharide administration affects the olfactory dopamine system in mice.2008

    • Author(s)
      Ota A, Mori K, Kaneko YS, Nakashima A, Nagatsu I, Nagatsu T.
    • Journal Title

      Ann N Y Acad Sci. 1148

      Pages: 127-135

    • Peer Reviewed
  • [Journal Article] A link between stress and depression : shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression.2008

    • Author(s)
      Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T.
    • Journal Title

      Stress. 11

      Pages: 198-209

    • Peer Reviewed
  • [Presentation] 施灸による前頭前野と線条体におけるドーパミン分泌2011

    • Author(s)
      深澤元晶
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
  • [Presentation] 施灸による体温上昇2011

    • Author(s)
      臼田信光
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
  • [Presentation] 施灸による脳内ドーパミン分泌に関するマイクロダイアリシス2010

    • Author(s)
      深澤元晶
    • Organizer
      Neuro 2010(第33回日本神経科学会大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
  • [Presentation] 施灸によるラット大脳基底核におけるドパミン分泌2010

    • Author(s)
      深澤元晶
    • Organizer
      第25回日本大脳基底核研究会
    • Place of Presentation
      福島
    • Year and Date
      2010-08-01
  • [Presentation] 施灸による線条体におけるドーパミン分泌2010

    • Author(s)
      深澤元晶
    • Organizer
      第115回日本解剖学会全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-29

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Published: 2012-01-26   Modified: 2019-05-27  

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