2010 Fiscal Year Final Research Report
Novel advances of adiponectin signal transduction network
| Project/Area Number |
20390254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAUCHI Toshimasa The University of Tokyo, 医学部附属病院, 講師 (40372370)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アディポネクチン / シグナル情報伝達 / 動脈硬化 |
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| Research Abstract |
Adiponectin induces extracellular Ca influx by adiponectin receptor 1 (AdipoR1), which was necessary for subsequent activation of CaMKKb and AMPK, increased expression PGC-1a, and increased mitochondria in myocytes. Moreover, muscle-specific disruption of AdipoR1 suppressed the adiponectin-mediated increase in intracellular Ca concentration, and decreased the activation of CaMKK and AMPK by adiponectin. Suppression of AdipoR1 also resulted in decreased PGC-1a expression, decreased mitochondrial content and enzymes, and decreased oxidative type I myofibres in skeletal muscle, which were associated with insulin resistance and decreased exercise endurance (Nature 464 : 1313,2010). Decreased levels of adiponectin and AdipoR1 in obesity may have causal roles in mitochondrial dysfunction and insulin resistance seen in diabetes.
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[Journal Article] Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca^<2+> and AMPK/SIRT1.2010
Author(s)
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi K.Y, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
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Journal Title
Nature 434
Pages: 1313-1319
Peer Reviewed
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[Journal Article] Rimonabant Ameliorates Insulin Resistance via both Adiponectin-dependent and Adiponectin-independent Pathways.2009
Author(s)
Watanabe T, Kubota N, Ohsugi M, Kubota T, Takamoto I, Iwabu M, Awazawa M, Katsuyama H, Hasegawa C, Tokuyama K, Moroi M, Sugi K, Yamauchi T, Noda T, Nagai R, Terauchi Y, Tobe K, Ueki K, Kadowaki T
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Journal Title
The Journal of Biological Chemistry 284
Pages: 1803-1812
Peer Reviewed
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[Journal Article] Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition.2008
Author(s)
Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A
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Journal Title
Peer Reviewed
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