2011 Fiscal Year Final Research Report
Molecular analysis of hematopoietic stem cell division in the niche
| Project/Area Number |
20390270
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | 再生医学 / 発生分化 |
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| Research Abstract |
In this project, we have analyzed the function of molecules associating with receptor tyrosine kinase Tie2 expressed on hematopoietic stem cells(HSCs). The functional or non-functional expression of PSF1, a member of GINS complex regulating DNA replication and self-renewal of HSCs, is alternatively regulated by the different translational initiation sites. It has been suggested that galectin-3 expressed on HSCs induces angiogenesis resulting in the induction of vascular niche formation for HSCs. Tie1 negatively regulated Tie2 mediated ERK activation through p38 activation. This downstream cascade of Tie1 may be relevant to the dormancy of HSCs.
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