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2010 Fiscal Year Final Research Report

Demonstration of serotonin hypothesis for autism by PET, and the identification and analysis of function on gene related to the control of serotonin synthesis

Research Project

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Project/Area Number 20390312
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAKAMURA Kazuhiko  Hamamatsu University School of Medicine, 医学部, 准教授 (80263911)

Co-Investigator(Kenkyū-buntansha) NAKEI Noriyoshi  浜松医科大学, 子どものこころの発達研究センター, 教授 (80206937)
OUCHI Yasuomi  浜松医科大学, 分子イメージング先端研究センター, 教授 (40436978)
TSUZII Masatsugu  中京大学, 現代社会学部, 教授 (20257546)
MATSUZAKI Hideo  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970)
KATAYAMA Taichi  大阪大学, 連合小児発達学研究科, 教授 (80333459)
IWATA Keiko  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (30415088)
IWATA Yasuhide  浜松医科大学, 医学部附属病院, 講師 (10285025)
TSUCHIYA Kenzi  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (20362189)
SUDA Shirou  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (40432207)
SUZUKI Katsuaki  浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00285040)
Project Period (FY) 2008 – 2010
Keywords児童・思春期精神医学 / 神経科学 / 脳・神経 / 自閉症 / PET / 遺伝子
Research Abstract

We showed the associations of factors related to the serotoninergic system with autism, in a trio association study. We further showed the significant difference of these factors' mRNA expression between the autistic and control groups in the postmortem brain. Thus, we suggest a possible role of these factors in the pathogenesis of autism. PET study indicated the gross abnormalities in the serotoninergic and cholinergic systems. A deficit in cholinergic innervations of the fusiform gyrus may be related to not only current but also childhood impairment of social functioning.

  • Research Products

    (34 results)

All 2011 2010 2009 2008 Other

All Journal Article (14 results) Presentation (13 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011

    • Author(s)
      Suzuki K, Genichi G, Ouchi Y, Nakamura K, Tsuiii M, Futatsubashi M, Iwata Y, Tsuchiya K, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
    • Journal Title

      Arch Gen Psychiatry. 68

      Pages: 306-313

  • [Journal Article] *corresponding author Replication study of Japanese cohorts supports the role of STXJA in autism susceptibility2011

    • Author(s)
      Nakamura K*, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada, Tsuiii M, Tsuchiva JK, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35

      Pages: 454-458

  • [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism.2010

    • Author(s)
      Kajizuka M, Miyachi T, Matsuzaki H, Iwata K Shinmura C, Suzuki K, Suda S, Tsuchiva KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 154-158

  • [Journal Article] Metabolite alterations in the hippocampus of high-functioning adult subjects with autism.2010

    • Author(s)
      Suzuki K, Nishimura K, Sugihara G, Nakamura K, Tsuchiva KJ, Matsumoto K, Takebayashi K, Isoda H, Sakahara H, Sugiyama T, Tsujii M, Takei N, Mori N.
    • Journal Title

      Int J Neuropsychopharmacol. 13

      Pages: 529-534

  • [Journal Article] Brain serotonin and dopamine transporter bindings in adults with high-functioning autism.2010

    • Author(s)
      Nakamura K, Sekine Y, Ouchi Y, Tsujii M, Yoshikawa E, Futatsubashi M, Tsuchiva KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Arch Gen Psychiatry. 67

      Pages: 59-68

  • [Journal Article] Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects.2010

    • Author(s)
      Maekawa M, Iwayama Y, Arai R, Nakamura K, Ohnishi T, Toyota T, Tsujii M, Okazaki Y, Osumi N, Owada Y, Mori N, Yoshikawa T.
    • Journal Title

      J Hum Genet. 55

      Pages: 127-130

  • [Journal Article] *corresponding author Decreased serum levels of adiponectin in subjects with autism.2010

    • Author(s)
      Fujita-Shimizu A, Suzuki K, Nakamura K*, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiva KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 455-458

  • [Journal Article] # These authors contributed equally to this work Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T#, Yokoyama S#, Nakamura K#, Anitha A#, Yamada K#, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Nods M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
    • Journal Title

      Neurosci Res. 67(2)

      Pages: 181-191

  • [Journal Article] *corresponding author Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I, Nakamura K*, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiva KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suds S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N.
    • Journal Title

      Neurosci Res. 68

      Pages: 137-141

  • [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient.2009

    • Author(s)
      Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T.
    • Journal Title

      Neurosci Lett. 462(3)

      Pages: 267-271

  • [Journal Article] *corresponding author Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.2008

    • Author(s)
      Anitha A, Nakamura K*, Yamada K, Suda S, Thanseem I, Tsuiji M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiva K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N Yoshikawa T, Mori N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B

      Pages: 1019-1027

  • [Journal Article] Paternal aye at birth and high-functioning autistic-spectrum disorder in offspring.2008

    • Author(s)
      Tsuchiva KJ, Matsumoto K, Miyachi T, Tsujii M, Nakamura K, Takagai S, Kawai M, Yagi A, Iwaki K, Suda S Sugihara G, Iwata Y, Matsuzaki H, Sekine Y, Suzuki K, Sugiyama T, Mori N, Takei N.
    • Journal Title

      Br J Psychiatry. 193

      Pages: 316-321

  • [Journal Article] *corresponding author Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism.2008

    • Author(s)
      Nakamura Kr*, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
    • Journal Title

      Int J Neuropsychopharmacol. 11

      Pages: 1073-1084

  • [Journal Article] Serum levels of P-selectin in men with high-functioning autism.2008

    • Author(s)
      Iwata Y, Tsuchiva KJ, Mikawa S, Nakamura K, Takai Y, Suda S, Sekine Y, Suzuki K, Kawai M, Sugihara G, Matsuzaki H, Hashimoto K, Tsujii M, Sugiyama T, Takei N, Mori N.
    • Journal Title

      Br J Psychiatry. 193

      Pages: 338-339

  • [Presentation] In vivo alterations in cerebral serotonin and dopamine systems in autism2010

    • Author(s)
      Ouch Y, Nakamura K Yoshikawa E, Futatsubashi M, Kikuchi M, Suzuki K, Tsuiii M, Mori N
    • Organizer
      International Conference on Brain Function and Development
    • Year and Date
      20100000
  • [Presentation] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism.2010

    • Author(s)
      Suzuki K, Ouchi Y, Nakamura K, Tsuiii M, Mori N
    • Organizer
      International Conference on Brain Function and Development
    • Year and Date
      20100000
  • [Presentation] Dyslipidemia in male patients with high-functioning autism.2010

    • Author(s)
      Matsuzaki H, Iwata K, Suda S, Tsuchiva KJ, Suzuki K, Nakamura K, Tsuiii M, Takei N, Mori N
    • Organizer
      9th Annual International Meeting For Autism Research
    • Year and Date
      20100000
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K, Ouchi Y, Tsujii M, Tsuchiva KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N.
    • Organizer
      Mori N 9th Annual International Meeting For Autism Research
    • Year and Date
      20100000
  • [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism.2010

    • Author(s)
      Nakamura K, Ouchi Y, Tsuiii M, Tsuchiva KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, Suda S, Sugiyama T, Takei N, Mori N
    • Organizer
      40th annual meeting of the Society for Neuroscience
    • Year and Date
      20100000
  • [Presentation] Genetic and Expression Analyses of Serotonergic Factors in Autism.2009

    • Author(s)
      Nakamura K, Miyachi T, Ayyappan A, Tsujii M, Suda S, Thanseem I, Tsuchiva K, Matsuzaki H,Yamada K, Iwayama Y, Toyota T, Hattori E, Sugiyama T, Takei N, Yoshikawa T, Mori N
    • Organizer
      8th Annual International Meeting For Autism Research
    • Year and Date
      20090000
  • [Presentation] Serotonin related gene expression changes in subjects with autism : a postmortem brain study.2009

    • Author(s)
      Suda S, Ieata K, Anitha A, Thanseem I, Matsuzaki H, Kameno Y, Nakamura K, Mori N, Takei N
    • Organizer
      39th annual meeting of the Society for Neuroscience
    • Year and Date
      20090000
  • [Presentation] Dyslipidemia in male patients with high-functioning autism.2009

    • Author(s)
      Matsuzaki H, Iwata K, Suda S, Tsuchiva KJ, Matsumoto K, Miyachi T, Suzuki K, Nakamura K, Tsuiii M, Takei N, Mori N
    • Organizer
      39th annual meeting of the Society for Neuroscience
    • Year and Date
      20090000
  • [Presentation] Genetic studies to elucidate the molecular mechanism of serotonergic dysfunction in autism.2008

    • Author(s)
      Anitha A, Nakamura K
    • Organizer
      XVIthe World Congree on Psychiatric Genetics
    • Year and Date
      20080000
  • [Presentation] Genetic analyses of serotonergic factors in autism2008

    • Author(s)
      Nakamura K, Matsuzaki H, Tsujii M, Ayyappan A, Yamada K, Suda S, Iwayama Y, Miyachi T, Tsuchiva K, Sugiyama T, Takei N, Yoshikawa T, Mori N
    • Organizer
      7th Annual International Meeting For Autism Research
    • Year and Date
      20080000
  • [Presentation] Serotonin transporter and serotonin related gene expression in autism.2008

    • Author(s)
      Suda S, Iwata K, Anitha A, Thanseem I, Nakamura K, Matsuzaki H Iwata Y, Yamamoto S, Suzuki K, Takei N, Koizumi K, Mori N
    • Organizer
      38th annual meeting of the Society for Neuroscience
    • Year and Date
      20080000
  • [Presentation] Wide-spread decreases of serum growth factors levels in male with high-functioning autism2008

    • Author(s)
      Matsuzaki H, Iwata Y, Tsuchiva JK, Sugihara G, Suda S, Suzuki K, Nakamura K, Tsuiii M, Takei N, Hashimoto K, Mori N
    • Organizer
      38th annual meeting of the Society for Neuroscience, Washington
    • Year and Date
      20080000
  • [Presentation] Brain serotonin and dopamine transporter densities in autism.2008

    • Author(s)
      Nakamura K
    • Organizer
      COE International Symposium 2008 on Development, Learning, Memory and Autism
    • Year and Date
      20080000
  • [Book] 子どもの発達と行動(身体と脳の検査・心に関する身体と脳の検査の現状)(最新の画像検査、飯田順三編集)(脳とこころのプライマリケア4)2010

    • Author(s)
      中村和彦
    • Total Pages
      88-96
    • Publisher
      シナジー
  • [Book] 一般精神科医のための子どもの心の診療テキスト(II,小児に心の問題が生じる原因1.遺伝、厚生労働省雇用均等・児童家庭局編集)2008

    • Author(s)
      中村和彦
    • Total Pages
      8-9
    • Publisher
      日本精神神経学会
  • [Book] 子どもの精神医学(子どもの精神医学における薬物治療について)(森則夫監修)(中村和彦編集)2008

    • Author(s)
      中村和彦
    • Total Pages
      147-156
    • Publisher
      金芳堂
  • [Book] 子どもの精神医学(広汎性発達障害と注意欠陥/多動性障害)(森則夫監修)(中村和彦編集)2008

    • Author(s)
      中村和彦
    • Total Pages
      174-197
    • Publisher
      金芳堂
  • [Remarks] ホームページ等

  • [Patent(Industrial Property Rights)] 高機能自閉症の発症危険度を判定する方法およびマーカー2010

    • Inventor(s)
      森則夫、中村和彦、鈴木勝昭、土屋賢治、岩口圭子、松崎秀夫
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Filing Date
      2010-10-14
  • [Patent(Industrial Property Rights)] 高機能自閉症の発症危険度を判定する方法およびマーカー2009

    • Inventor(s)
      森則夫、中村和彦、鈴木勝昭、土屋賢治、岩田圭子、松崎秀夫
    • Industrial Property Rights Holder
      国立大学法人浜松医科大学
    • Industrial Property Number
      特願2009-236976,PCT/JP2010/006114
    • Filing Date
      2009-10-14

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Published: 2012-01-26   Modified: 2016-04-21  

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