2010 Fiscal Year Final Research Report
Radionuclide imaging for tissue characterization and treatment effect of experimental atherosclerosis
| Project/Area Number |
20390321
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAMAKI Nagara Hokkaido University, 大学院・医学研究科, 教授 (30171888)
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| Co-Investigator(Kenkyū-buntansha) |
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 動脈硬化 / 不安定プラーク / 核医学診断 |
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| Research Abstract |
In order to assess atheroma vulnerability, we have selected two radiopharmaceuticals to probe atheroma imaging in vivo using apolipoprotein E knockout (apoE-/-) mice. The uptakes of FDG and Annexin A5 were quantitatively measured on autoradiography to compare with various parameters on histological and immunohistochemical staining. These uptakes were closely correlated with atheroma staging and macrophage infiltration. The current study indicated that the radionuclide imaging has a potential to identify atheroma vulnerability.
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