2011 Fiscal Year Final Research Report
Research on the usefulness of newly developed hypoxia imaging agent for PET for a tailor-made treatment of cancer
| Project/Area Number |
20390322
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University (2010-2011)
Tohoku University (2008-2009) |
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Principal Investigator |
TAKAI Yoshihiro 弘前大学, 大学院・医学研究科, 教授 (50107653)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAYA Mutsuo 東北大学, 大学院・医学系研究科, 教授(寄付講座) (60261640)
HOSHIKAWA Yasushi 東北大学, 大学院・医学系研究科, 助教 (90333814)
KANETA Tomohiro 東北大学, 大学院・医学系研究科, 助教 (50323019)
NAKATA Eiko 東北大学, 大学院・医学系研究科, 助教 (60375201)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 核医学(PETを含む) |
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| Research Abstract |
[18F]FRP170,1-(2-fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, is a new PET tracer for imaging hypoxia which was developed by the principal researcher and his colleagues of this Grant-in-Aid for Scientific research. The usefulness of [18F]FRP-170 for a treatment for a tailor-made treatment of cancer was investigated by looking at the relationship between the rate of FRP-170 uptake of tumor and the radiation responsiveness, the hypoxia related gene expression in the resected lung cancer, benign or malignant glioma, and O2 partial pressure in the malignant glioma. The results obtained from these clinical investigation were all positive for the usefulness of the drug. [18F]FRP-170, therefore, is strongly suggested to be a promising new hypoxia marker to establish a tailor-made-treatment of cancer.
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Research Products
(32 results)
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[Journal Article] Impact of pathological tumor stage forsalvage radiotherapy after radicalprostatectomy in patients withprostate-specific antigen<1.0 ng/ml2011
Author(s)
Umezawa R, Ariga H, Ogawa Y, Jingu K, Matsushita H, Takeda K, Fujimoto K, Sakayauchi T, Sugawara T, Kubozono M, Narazaki K, Shimizu E, Takai Y Yamada S
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer : can SBRT be comparable to surgery?2011
Author(s)
Onishi H, Shirato H, Nagata Y, Hiraoka M, Fujino M, Gomi K, Karasawa K, Hayakawa K, Niibe Y, Takai Y, Kimura T, Takeda A, Ouchi A, Hareyama M, Kokubo M, Kozuka T, Arimoto T, Hara R, Itami J, Araki T
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 81
Pages: 1352-8
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitro-imidazole a new 18F-labeled 2-nitro-imidazole analog2010
Author(s)
Shibahara I, Kumabe T, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T
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Journal Title
J Neurosurg
Volume: 113
Pages: 358-68
Peer Reviewed
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[Journal Article] Focal dose escalation using FDG-PET-guided intensity-modulated radiation therapy boost for post operative local recurrent rectal cancer : a planning study with comparison of DVH and NTCP2010
Author(s)
Jingu K, Ariga H, Kaneta T, Takai Y, Takeda K, Katja L, Narazaki K, Metoki T, Fujimoto K, Umezawa R, Ogawa Y, Nemoto K, Koto M, Mitsuya M, Matsufuji N, Takahashi S, Yamada S
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Journal Title
BMC Cancer
Volume: 10
Pages: 127
Peer Reviewed
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[Journal Article] (18)F-fluorodeoxyglucose positron emission tomography immediately after chemoradiotherapy predicts prognosis in patients with locoregional postoperative recurrent esophageal cancer2010
Author(s)
Jingu K, Kaneta T, Nemoto K, Takeda K, Ogawa Y, Ariga H, Koto M, Sakayauchi T, Takai Y, Takahashi S, Yamada S
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Journal Title
Int J Clin Oncol
Volume: 15
Pages: 184-90
Peer Reviewed
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[Journal Article] Lymphoscintigraphy for sentinel lymph node mapping in Japanese patients with malignant skin neoplasms of the lower extremities : comparison with previously investigated Japanese lymphatic anatomy2010
Author(s)
Miura H, Ono S, Nagahata M, Shibutani K, Kakehata S, Morimoto K, Seino H, Kakuta A, Aoki M, Hatayama Y, Kawaguchi H, Takai Y, Abe Y, Kaneko T, Sawamura D, Hanada K
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Journal Title
Ann Nucl Med
Volume: 24
Pages: 601-8
Peer Reviewed
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[Book] Mundt AJ, Roeske JC (Editors)2011
Author(s)
Bowsher J, Takai Y, et al
Total Pages
615
Publisher
People's Medical Publishing House, Image-Guided Radiation Therapy Emerging in-room imaging technology
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