Volumetric modulated arc therapy (VMAT) and in-VMAT cone beam CT

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390325
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAGAWA Keiichi The University of Tokyo, 医学部附属病院, 準教授 (80188896)
• Co-Investigator(Kenkyū-buntansha): TERAHARA Atsuro 東邦大学, 医学部附属病院, 教授 (80237007) ; YAMASHITA Hideomi 東京大学, 医学部附属病院, 助教 (70447407) ; SHIRAISHI Kenshiro 東京大学, 医学部附属病院, 助教 (40447404) ; IGAKI Hiroshi 東京大学, 医学部附属病院, 講師 (90361344) ; MASUTANI Yoshitaka 東京大学, 医学部附属病院, 講師 (20345193) ; NISHIO Teiji 国立がん研究センター東病院, 臨床開発センター粒子線生物学, 室長 (40415526) ; GOMI Tsutomu 北里大学, 医療衛生学部, 講師 (10458747)
• Project Period (FY): 2008 – 2010
• Keywords: 強度変調原体照射法 / 同時CT撮影 / 高精度放射線治療 / 放射線治療 / 定位放射線治療 / 画像誘導放射線治療

Research Abstract

The authors established volumetric modulated arc therapy (VMAT) which is combined avoidance technique and dose-rate modulation. Three-dimensional tumor position during M was developed in-VMAT kilovoltage (kV) cone-beam CT (CBCT) to ensure treatment quality. Treatment time required for VMAT was about 2 min while 5~10min in conventional IMRT. The mean and standard deviation of displacements at the time of pre-treatment against the intreatment position of all the six days for the patient were 0.1±0.2mm, -0.3±0.4mm, -0.4±0.6mm in lateral, vertical, and longitudinal directions.

Research Products

• [Journal Article] Cone beam computed tomography data acquisition during VMAT delivery with subsequent respiratory phase sorting based on projection image cross-correlation. (2011)
  • Author(s): Nakagawa K, Kida S, Haga A, Masutani Y, Yamashita H, Imae T, Tanaka K, Ohtomo K, Iwai Y, Yoda K
  • Journal Title: J Radiat Res (Tokyo). PubMed PMID: 21293076 52(1) Pages: 112-113
  • Peer Reviewed
• [Journal Article] Details of recurrence sites after elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT) combined with chemotherapy for thoracic esophageal squamous cell carcinoma--a retrospective analysis. (2010)
  • Author(s): Yamashita H, Okuma K, Wakui R, Kobayashi-Shibata S, Ohtomo K, Nakagawa K
  • Journal Title: Radiother Oncol. PubMed PMID: 21074880 98(2) Pages: 255-260
  • Peer Reviewed
• [Journal Article] Four-dimensional measurement of the displacement of internal fiducial markers during 320-multislice computed tomography scanning of thoracic esophageal cancer. (2010)
  • Author(s): Yamashita H, Kida S, Sakumi A, Haga A, Ito S, Onoe T, Okuma K, Ino K, Akahane M, Ohtomo K, Nakagawa K.
  • Journal Title: Int J Radiat Oncol Biol Phys. PubMed PMID: 20678869 79(2) Pages: 588-95
  • Peer Reviewed
• [Journal Article] Patient setup error and day-to-day esophageal motion error analyzed by cone-beam computed tomography in radiation therapy. (2010)
  • Author(s): Yamashita H, Haga A, Hayakawa Y, Okuma K, Yoda K, Okano Y, Tanaka K, Imae T, Ohtomo K, Nakagawa K
  • Journal Title: Acta Oncol. PubMed PMID: 20230211 49(4) Pages: 485-90
  • Peer Reviewed
• [Journal Article] The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy. (2010)
  • Author(s): Nishio T, Miyatake A, Ogino T, Nakagawa K, Saijo N, Esumi H
  • Journal Title: Int J Radiat Oncol Biol Phys. PubMed PMID: 20005459 76(1) Pages: 277-86
  • Peer Reviewed
• [Journal Article] First report on prostate displacements immediately before and after treatment relative to the position during VMAT delivery. (2009)
  • Author(s): Nakagawa K, Shiraishi K, Kida S, Haga A, Yamamoto K, Saegusa S, Terahara A, Itoh S, Ohtomo K, Yoda K
  • Journal Title: Acta Oncol. PubMed PMID: 19863231 48(8) Pages: 1206-1208
  • Peer Reviewed
• [Journal Article] Quality assurance of volumetricmodulated arc therapy using Elekta Synergy. (2009)
  • Author(s): Haga A, Nakagawa K, Shiraishi K, Itoh S, Terahara A, Yamashita H, Ohtomo K, Saegusa S, Imae T, Yoda K, Pellegrini R
  • Journal Title: Acta Oncol. PubMed PMID: 19863228. 48(8) Pages: 1193-1197
  • Peer Reviewed
• [Journal Article] Pellegrini R.Quality assurance of volumetric modulated arc therapy using Elekta Synergy. (2009)
  • Author(s): Haga A, Nakagawa K, Shiraishi K, Itoh S, Terahara A, Yamashita H, Ohtomo K, Saegusa S, Imae T, Yoda K
  • Journal Title: Acta Oncol. PubMed PMID: 19639466 29 Pages: 1-5
  • Peer Reviewed
• [Journal Article] First report on prostate displacements immediately before and after treatment relative to the position during VMAT delivery. (2009)
  • Author(s): Nakagawa K, Shiraishi K, Kida S, Haga A, Yamamoto K, Saegusa S, Terahara A, Itoh S, Ohtomo K, Yoda K
  • Journal Title: Acta Oncol. PubMed PMID: 19634051. 25(Epub ahead of print) Pages: 1-2
  • Peer Reviewed
• [Journal Article] First clinical cone-beam CT imaging during volumetric modulated arc therapy. (2008)
  • Author(s): Nakagawa K, Haga A, Shiraishi K, Yamashita H, Igaki H, Terahara A, Ohtomo K, Saegusa S, Shiraki T, Oritate T, Yoda K.
  • Journal Title: Radiother Oncol. PubMed PMID: 19062117. 90(3) Pages: 422-423
  • Peer Reviewed
• [Presentation] Tracking Volume Change during IMRT treatment using non-rigid registration. (2010)
  • Author(s): A.Haga, T.Matsuura, S.Kida, S.Itoh, N.Saotome, K.Shiraishi, A.Sakumi, J.Kotoku, A.Terahara, K.Nakagawa.
  • Organizer: ESTRO 29
  • Place of Presentation: CCIB, Barcelona, SPAIN
  • Year and Date: 20100912-20100916
• [Presentation] Comparison of treatment planning systems in Elekta Volumetric Modulated Arc Thearpy (Elekata VMAT)-prostate cancer study (2010)
  • Author(s): A.Haga, S.Kida, Y.Okano, S.Itoh, T.Matsuura, N.Saotome, A.Sakumi, J.Kotoku, K.Shiraishi, K.Nakagawa, Y.Iwai
  • Organizer: AAPM 52
  • Place of Presentation: Pennsylvania Convention Center, Pennsylvania, USA
  • Year and Date: 20100718-20100722
• [Presentation] Influence of gantry angle, multi-leaf collimator (MLC), and jaw position errors to dose distribution in Volumetric Modulated Arc Therapy (VMAT) (2009)
  • Author(s): A.Haga, K.Nagagawa, K.Shiraishi, S.Itoh, S.Saegusa, T.Imae, K.Sasaki, S.Kida, A.Terahara, K.Yoda
  • Organizer: AAPM 51
  • Place of Presentation: Anaheim Convention Center, Anaheim, USA
  • Year and Date: 20090726-20090730
• [Presentation] Physical aspects of Volumetric Modulated Arc Therapy (VMAT) using Elekta Synergy and ERGO++ treatment planning system. (2008)
  • Author(s): Akihiro Haga, K.Nakagawa, K.Shiraishi, K.Ohtomo, Y.Okano, T.Oritate, K.Yoda, R.G.Pellegrini
  • Organizer: ASTRO 50
  • Place of Presentation: Boston Convention & Exhibition Center, Boston, America
  • Year and Date: 20080921-20080925
• [Presentation] Physical aspects of Volumetric Modulated Arc Therapy (VMAT) using Elekta Synergy and ERGO++ treatment planning system. (2008)
  • Author(s): Akihiro Haga, K.Nakagawa, K.Shiraishi, K.Ohtomo, Y.Okano, T.Oritate, K.Yoda
  • Organizer: ESTRO 27
  • Place of Presentation: Goteberg Convention Center, Goteberg, Sweden
  • Year and Date: 20080914-20080918
• [Book] 癌放射線治療ハンドブック(改訂3版) (2011)
  • Author(s): 中川恵一、山下英臣
  • Total Pages: 99
  • Publisher: 中外医学社
• [Book] がんの正体 (2010)
  • Author(s): 中川恵一
  • Total Pages: 191
  • Publisher: PHP研究所
• [Book] 死を忘れた日本人 (2010)
  • Author(s): 中川恵一
  • Total Pages: 255
  • Publisher: 朝日出版社
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 呼吸同期用信号生成装置 (2009)
  • Inventor(s): 中川恵一
  • Industrial Property Rights Holder: 中川恵一
  • Industrial Property Number: 特許,特願2009-257060
  • Filing Date: 2009-11-10