2010 Fiscal Year Final Research Report
Quantitative neuroreceptor imaging for mice using PET : development of micro litter ordered blood radioactivity counting system and the technique to omit arterial blood sampling
| Project/Area Number |
20390333
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KIMURA Yuichi National Institute of Radiological Sciences, 分子イメージング研究センター, チームリーダ (60205002)
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| Co-Investigator(Kenkyū-buntansha) |
TOYAMA Hiroshi 藤田保健衛生大学, 医学部・放射線医学教室, 准教授 (90247643)
KITAMURA Keishi (株)島津製作所, 基盤技術研究所, 課長 (30395941)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Makoto 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダ (10373359)
SHIDAHARA Miho 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20443070)
HONTANI Hidekata 名古屋工業大学, 工学系研究科, 教授 (60282688)
SEKI Chie 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (40443080)
NISHIMOTO Takahiro (株)島津製作所, 基盤技術研究所, 部長
WADA Yasuhiro 独立行政法人理化学研究所, 分子イメージング科学研究センター, 副チームリーダ
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| Research Collaborator |
NAGANAWA Mika 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員
SAKAGUCHI Kazuya 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子イメージング / 核医学 / 脳 / トランスレーショナルリサーチ / マウス |
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| Research Abstract |
In this study, the methods for radioactivity counting system for micro-liter ordered blood were investigated. Also, the algorithm to omit arterial blood sampling was studied. For fully quantitative functional imaging using positron emission tomography (PET), the radioactivity concentration in arterial blood is required, and therefore, arterial blood sampling should be conducted. However, due to the small size in mice, the arterial blood sampling is an issue for PET quantitative measurement. This study aimed to realize quantitative PET functional imaging for mice, the system to measure radioactivity concentration in a few micro-liter arterial blood and the algorithm fo reduce the noise in PET data derived from mice based on MAP estimation were investigated.
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[Presentation] MAP-based Denoising of Dynamic PET Data for Quantitative Receptor Imaging2011
Author(s)
Naoki Hoshino, Hidekata Hontani, Kazuya Sakaguchi, Muneyuki Sakata, Kiichi Ishiwata, Yuichi Kimura
Organizer
Conference of Biomedical Applica-tions in Molecular, Structural, and Functional Imaging (Conference 7965), SPIE Medical Imag-ing 2011(7965-7943)
Place of Presentation
Orland,FL,USA
Year and Date
20110212-20110217
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[Patent(Industrial Property Rights)] 測定システム2010
Inventor(s)
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Rights Holder
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Number
特許,特願2010-068152,PCT/JP2010/007603
Filing Date
2010-12-28
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[Patent(Industrial Property Rights)] 測定システム2010
Inventor(s)
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Rights Holder
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Number
特願2010-68151,PCT/JP2010/007602
Filing Date
2010-10-28
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[Patent(Industrial Property Rights)] Measuring Appratus, and Liquid Collecting and Measuring System Having the Same2010
Inventor(s)
木村裕一, Keishi Kitamura, Takahiro Nishimoto, Chie Seki, Iwao Kanno
Industrial Property Rights Holder
Yuichi Kimura, Keishi Kitamura, Takahiro Nishimoto, Chie Seki, Iwao Kanno
Industrial Property Number
特許,PCT/JP2008/050803,087036471.,12/863,968
Filing Date
2010-10-13
Overseas
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[Patent(Industrial Property Rights)] 遠心分離装置2009
Inventor(s)
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Rights Holder
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Number
特許,特願2009-227513
Filing Date
2009-09-30
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[Patent(Industrial Property Rights)] 液体採取装置、測定装置並びにそれらを備えた液体採取測定システム2008
Inventor(s)
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Rights Holder
木村裕一,橋爪宣弥,北村圭司,西本尚弘,関千江,菅野巖
Industrial Property Number
特許,PCT/JP2008/050803
Filing Date
20080122,20090730
