NOVEL DIAGNOSTIC AND THERAPEUTIC STRATEGY FOR AORTIC ANEURYSM

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390348
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Research Institute, International Medical Center of Japan
• Principal Investigator: HIROE Michiaki Research Institute, International Medical Center of Japan, 循環器科, 部長 (80101872)
• Co-Investigator(Kenkyū-buntansha): KIMURA Sosuke 国立国際医療研究センター(研究所), 戸山病院, 院長 (30118450) ; SHIGEMATSU Hiroshi 東京医科大学, 医学部, 教授 (40134556) ; OBITSU Yukio 東京医科大学, 医学部, 准教授 (10233610) ; YOSHIDA Kyoko (今中 恭子) 三重大学, 大学院・医学系研究科, 准教授 (00242967) ; AOKI Hiroki 久留米大学, 循環器病研究所, 准教授 (60322244) ; YOSHIMURA Koichi 山口大学, 医学部, 准教授 (00322248)
• Project Period (FY): 2008 – 2010
• Keywords: 大動脈瘤 / バイオマーカー / 病態生理 / 分子病態

Research Abstract

Abdominal aortic aneurysm (AAA) is a fatal disease caused by the segmental weakening and dilation of aorta. In this project we found that tenascin-C (TNC), a matricellular protein, was expressed at the active lesion of AAA and may protect the aortic tissue. We also found that higher level of serum TNC was associated with the better outcome after the endovascular repair of AAA, suggesting that serum TNC level may be an useful biomarker in this context.

Research Products

• [Journal Article] Tenascin-C is expressed in abdominal aortic aneurysm tissue withactive degradation process. (2011)
  • Author(s): Kimura T., Yoshimura K., Aoki H., Imanaka-Yoshida K., Yoshida T., Ikeda Y., Morikage N., Endo H., Hamano K., Imaizumi T., Hiroe M., Aonuma K., Matsuzaki M.
  • Journal Title: Pathol Intern (in press)
• [Journal Article] Tenascin C may regulate the recruitment of smooth muscle cells during coronary artery development. (2011)
  • Author(s): Ando K., Takahashi M., Yamagishi T., Miyagawa-Tomita S., Imanaka-Yoshida, Toshimichi Yoshida K., Nakajima Y.
  • Journal Title: Differentiation (in press)
• [Journal Article] Matricelular proteins-New molecular targets to prevent heart failure. (2011)
  • Author(s): Okamoto H., Imanaka-Yoshida K.
  • Journal Title: Cardiovasc.Ther. (in press)
• [Journal Article] Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue. (2011)
  • Author(s): Shintani Y., Nishihara M., Ohno S., Furusho A., Aoki H., Hiromatsu S.-i., Akashi, H., Imaizumi, T., Aoyagi S.
  • Journal Title: Atherosclerosis (in press)
• [Journal Article] Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm. (2011)
  • Author(s): Kaneko H., Anzai T., Takahashi T., Kohno T., Shimoda M., Sasaki A., Shimizu H., Nagai T., Maekawa Y., Yoshimura K., Aoki H., Yoshikawa T., Okada Y., Yozu R., Ogawa S., Fukuda K.
  • Journal Title: Cardiovasc Res (in press)
• [Journal Article] Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. (2011)
  • Author(s): Nagaharu K., Zhang X., Yoshida T., Katoh D., Hanamura N., Kozuka Y., Ogawa T., Shiraishi T., Imanaka-Yoshida K.
  • Journal Title: Am J Pathol. 178 Pages: 754-63
• [Journal Article] Developmental defects of coronary vasculature in rat embryos administered bis-diamine. (2011)
  • Author(s): Hanato T., Nakagawa M., Okamoto N., Nishijima S., Fujino H., Shimada M., Takeuchi Y., Imanaka-Yoshida K.
  • Journal Title: Birth Defects Res B Dev Reprod Toxicol. 92 Pages: 10-6
• [Journal Article] Transfection of human HGF plasmid DNA improves limb salvage in Buerger's disease patients with critical limb ischemia. (2011)
  • Author(s): Shigematsu H., Yasuda K., Sasajima T., Takano T., Miyata T., Ohta T., Tanemoto K., Obitsu Y., Iwai T., Ozaki S., et al.
  • Journal Title: Int Angiol 30 Pages: 140-149
• [Journal Article] Obstructive sleep apnea as a potential risk factor for aortic disease. (2011)
  • Author(s): Saruhara H., Takata Y., Usui Y., Shiina K., Hashimura Y., Kato K., Asano K., Kawaguchi S., Obitsu Y., Shigematsu H., et al.
  • Journal Title: Heart Vessels. (in press)
• [Journal Article] Staged hybrid repair using telescoped stent graft fixation for aortic arch and descending aortic aneurysms. (2011)
  • Author(s): Koizumi N., Obitsu Y., Saiki N., lida Y., Kawaguchi S., Shigematsu H.
  • Journal Title: J Vasc Surg.
• [Journal Article] Tenascin-Cenhances crosstalk signaling of integrin alphavbeta3/PDGFR-beta complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells. (2010)
  • Author(s): Ishigaki T., Imanaka-Yoshida K., Shimojo N., Matsushima S., Taki W., Yoshida T.
  • Journal Title: J Cell Physiol(Epub ahesd of prints) 28
• [Journal Article] Dynamic expression of tenascin-C after myocardial ischemia and reperfusion : assessment by 1251-anti-tenascin-C antibody imaging. (2010)
  • Author(s): Taki J., Inaki A., Wakabayashi H., Imanaka-Yoshida K., Ogawa K., Hiroe M., Shiba K., Yoshida T., Kinuya S.
  • Journal Title: J Nucl Med. 51 Pages: 1116-22
• [Journal Article] Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice. (2010)
  • Author(s): Nishioka T., Onishi K., Shimojo N., Nagano Y., Matsusaka H., Ikeuchi M., Ide T., Tsutsui H., Hiroe M., Yoshida T., Imanaka-Yoshida K.
  • Journal Title: Am J Physiol Heart Circ Physiol. 298 Pages: H1072-8
• [Journal Article] Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells. (2010)
  • Author(s): Akada J.K., Aoki H., Torigoe Y., Kitagawa T., Kurazono H., Hoshida H., Nishikawa J., Terai S., Matsuzaki M., Hirayama T., Nakazawa T., Akada R., Nakamura K.
  • Journal Title: Dis Model Mech 3 Pages: 605-617
• [Journal Article] Isoform Specific Roles of Protein Phosphatase 1 Catalytic Subunits in Sarcoplasmic Reticulum-Mediated Ca2+ Cycling. (2010)
  • Author(s): Aoyama H., Ikeda Y., Miyazaki Y., Yoshimura K., Nishino S., Yamamoto T., Yano M., Inui M., Aoki H., Matsuzaki M.
  • Journal Title: Cardiovasc Res 89 Pages: 79-88
• [Journal Article] Celiac artery coverage after occlusion test during endovascular stent grafting for thoracoabdominal aortic aneurysm. (2010)
  • Author(s): Shimazaki T., Kawaguchi S., Yokoi Y., Koide K., Matsumoto M., Shigematsu, H.
  • Journal Title: J Thorac Cardiovasc Surg 139 Pages: e59-62
• [Journal Article] Randomized, double-blind, placebo-controlled clinical trial of hepatocyte growth factor plasmid for critical limb ischemia. (2010)
  • Author(s): Shigematsu H., Yasuda K., Iwai T., Sasajima T., Ishimaru S., Ohashi Y., Yamaguchi T., Ogihara T., Morishita R.
  • Journal Title: Gene Ther 17 Pages: 1152-1161
• [Journal Article] Three-year cardiovascular events and disease progress in patients with peripheral arterial disease : results from the Japan Medication Therapy for Peripheral Arterial Disease (J-METHOD). (2010)
  • Author(s): Shigematsu H., Nishibe T., Obitsu Y., Matsuzaki K., Ishida A., Miyata T., Shindo S., Hida K., Ohta T., Ando M., et al.
  • Journal Title: Int Angiol 29 Pages: 2-13
• [Journal Article] Long-term result of hybrid procedure for an extensive thoracic aortic aneurysm in Takayasu arteritis : a case report. (2010)
  • Author(s): Obitsu Y., Koizumi N., Saiki N., Kawaguchi S., Shigematsu H.
  • Journal Title: J Cardiothorac Surg 5 Pages: 28
• [Journal Article] Surgical repair for aortic dissection accompanying a right-sided aortic arch. (2010)
  • Author(s): Obitsu Y., Koizumi N., Iwahashi T., Saiki N., Shigematsu H.
  • Journal Title: J Cardiothorac Surg 5 Pages: 35
• [Journal Article] Long-term results of second-stage thoracic endovascular aortic repair following total aortic arch replacement. (2010)
  • Author(s): Obitsu Y., Koizumi N., lida Y., Iwahashi T., Saiki N., Watanabe Y., Takae H., Kawaguchi S., Shigematsu H.
  • Journal Title: Gen Thorac Cardiovasc Surg 58 Pages: 501-505
• [Journal Article] The education system to master endovascular aortic repair in Japan-the Japanese Committee for Stentgraft Management. (2010)
  • Author(s): Obitsu Y., Ishimaru S., Shigematsu H.
  • Journal Title: Fur J Vasc Endovasc Surg 39Suppl 1 Pages: S5-9
• [Journal Article] Expression and localization of vascular endothelial growth factor in normal abdominal aorta and abdominal aortic aneurysm. (2010)
  • Author(s): Nishibe T., Dardik A., Kondo Y., Kudo F., Muto A., Nishi M., Nishibe M., Shigematsu H.
  • Journal Title: Int Angiol 29 Pages: 260-265
• [Journal Article] Left atrial myxoma associated with acute myocardial infarction and multiple cerebral infarctions: Report of a case. (2010)
  • Author(s): Konagai N., Cho M., Shigematsu H.
  • Journal Title: Surg Today 40 Pages: 1159-1163
• [Journal Article] Left atrial myxoma as a cause of acute myocardial infarction. (2010)
  • Author(s): Konagai N., Cho M., Nakamura K., Shigematsu H.
  • Journal Title: Tex Heart Inst J 37 Pages: 125-126
• [Journal Article] Successful treatment of multiple mycotic aortic aneurysms, using a hybrid procedure. (2010)
  • Author(s): Iida Y., Obitsu Y., Yokoi Y., Komai H., Kawaguchi S., Shigematsu H.
  • Journal Title: J Vasc Surg 51 Pages: 1521-1524
• [Journal Article] A case of abdominal aortic aneurysm associated with L-shaped crossed-fused renal ectopia. (2010)
  • Author(s): Iida Y., Obitsu Y., Sugimoto T., Yamamoto K., Yoshii S., Shigematsu, H.
  • Journal Title: Ann Vasc Surg 24 Pages: 1137 e1131-1135
• [Journal Article] Surgical technique of total arch replacement for failed thoracic endovascular aortic repair. (2010)
  • Author(s): Iida Y., Obitsu Y., Koizumi N., Yokoi Y., Kawaguchi S., Shigematsu H.
  • Journal Title: Ann Thorac Surg 90 Pages: 677-678
• [Journal Article] Novel Role of Antioxidant-1 (Atoxl) as a Copper-dependent Transcription Factor Involved in Cell Proliferation. (2010)
  • Author(s): Itoh S., Kim H.W., Nakagawa O., Ozumi K., Lessner S.M., Aoki H., Akram K., McKinney R.D., Ushio-Fukai,M., Fukai T
  • Journal Title: J Biol Chem 283 Pages: 9157-9167
• [Journal Article] Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure. (2009)
  • Author(s): Fujimoto N., Onishi K., Sato A., Terasaki F., Tsukada B., Nozato T., Yamada T., Imanaka-Yoshida K., Yoshida T., Ito M., Hiroe M.
  • Journal Title: J Card Fail. 15 Pages: 898-905
• [Journal Article] Deficiency of tenascin-C delays articular cartilage repair in mice. (2009)
  • Author(s): Okamura N., Hasegawa M., Nakoshi Y., Iino T., Sudo A., Imanaka-Yoshida K., Yoshida T., Uchida A.
  • Journal Title: Osteoarthritis Cartilage. 18 Pages: 839-48
• [Journal Article] T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation. (2009)
  • Author(s): Shirai M., Imanaka-Yoshida K., Schneider M.D., Schwartz R.J., Morisaki T.
  • Journal Title: Proc Natl Acad Sci U S A. 106 Pages: 18604-9
• [Journal Article] Tenascin-C is induced in cerebral vasospasm after subarachnoid hemorrhage in rats and humans : a pilot study. (2009)
  • Author(s): Suzuki H., Kanamaru K., Suzuki Y., Aimi Y., Matsubara N., Araki T., Takayasu M., Kinoshita N., Imanaka-Yoshida K., Yoshida T., Taki W.
  • Journal Title: Neurol Res. 32 Pages: 179-84
• [Journal Article] High prevalence of chronic myocarditis in dilated cardiomyopathy referred for left ventriculoplasty : expression of tenascin C as a possible marker for inflammation. (2009)
  • Author(s): Tsukada B., Terasaki F., Shimomura H., Otsuka K., Katashima T., Fujita S., Imanaka-Yoshida K., Yoshida T., Hiroe M., Kitaura Y.
  • Journal Title: Hum Pathol. 40 Pages: 1015-22
• [Journal Article] RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells. (2009)
  • Author(s): Oda H., Fujimoto M., Patrick M.S., Chida D., Sato Y., Azuma Y., Aoki H., Abe T., Suzuki H., Shirai
  • Journal Title: J Immunol 182 Pages: 957-962
• [Journal Article] Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm. (2009)
  • Author(s): Onoda M., Yoshimura K., Aoki H., Ikeda Y., Morikage N., Furutani A., Matsuzaki M., Hamano K.
  • Journal Title: Atherosclerosis 208 Pages: 366-369
• [Journal Article] Clinical comparison of two different types of bifurcated graft for postoperative baPWV and ABI. (2009)
  • Author(s): Iwahashi T., Obitsu Y., Koizumi N., Shiraishi Y., Shigematsu H.
  • Journal Title: Int Angiol 28 Pages: 232-237
• [Journal Article] Successful coil embolization for rupture of the subclavian artery associated with Ehlers-Danlos syndrome type IV. (2009)
  • Author(s): Iida Y., Obitsu Y., Komai H., Shigematsu H.
  • Journal Title: J Vase Surg 50 Pages: 1191-1195
• [Journal Article] Prevalence of coronary heart disease in patients with aortic aneurysm and/or peripheral artery disease. (2009)
  • Author(s): Hirose K., Chikamori T., Hida S., Tanaka H., Igarashi Y., Watanabe Y., Koizumi N., Kawaguchi S., Obitsu Y., Shigematsu H., et al.
  • Journal Title: Am J Cardiol 103 Pages: 1215-1220
• [Journal Article] Thoracic endovascular aneurysm repair in Japan : Experience with fenestrated stent grafts in the treatment of distal arch aneurysms. (2009)
  • Author(s): Kawaguchi S., Yokoi Y., Shimazaki T., Koide K., Matsumoto M., Shigematsu H.
  • Journal Title: J Vase Surg(discussion 29S) 48 Pages: 24S-29S
• [Journal Article] Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation. (2008)
  • Author(s): Ishii K., Imanaka-Yoshida K., Yoshida T., Sugimura Y.
  • Journal Title: Dev Biol. 324 Pages: 310-9
• [Journal Article] Basic fibroblast growth factor slow release stent graft for endovascular aortic aneurysm repair : a canine model experiment. (2008)
  • Author(s): Kajimoto M., Shimono T., Hirano K., Miyake Y., Kato N., Imanaka-Yoshida K., Shimpo H., Miyamoto K.
  • Journal Title: J Vase Surg. 48 Pages: 1306-14
• [Journal Article] Conventional therapy with an ACE inhibitor diminishes left ventricular dyssynchrony during the progression of heart failure. (2008)
  • Author(s): Kurita T., Onishi K., Dohi K., Takamura T., Fujimoto N., Tanigawa T., Imanaka-Yoshida K., Wada H., Nobori T., Ito M.
  • Journal Title: Int J Cardiol. 140 Pages: 48-54
• [Journal Article] Atrial natriuretic peptide gene transfection with a novel envelope vector system ameliorates pulmonary hypertension in rats. (2008)
  • Author(s): Mitani Y., Maruyama J., Jiang B.H., Sawada H., Shimpo H., Imanaka-Yoshida K., Kaneda Y., Komada Y., Maruyama K.
  • Journal Title: J Thorac Cardiovasc Surg. 136 Pages: 142-9
• [Journal Article] Identification of cardiac-specific myosin light chain kinase. (2008)
  • Author(s): Chan J.Y., Takeda M., Briggs L.E., Graham M.L., Lu,J.T., Horikoshi N., Weinberg E.O., Aok, H., Sato N., Chien K.R., Kasahara H.
  • Journal Title: Circ Res 102 Pages: 571-580
• [Journal Article] Role of NonO-histone interaction in TNFalpha-suppressed prolyl-4-hydroxylase alphal. (2008)
  • Author(s): Zhang C., Zhang M.X., Shen Y.H., Burks J.K., Li X.N., LeMaire S.A., Yoshimura K., Aoki H., Matsuzaki M., An F.S., Engler D.A., Matsunami R.K., Coselli J.S., Zhang Y., Wang X.L.
  • Journal Title: Biochim Biophys Acta 1783 Pages: 1517-1528
• [Journal Article] Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111 In Fab fragment of monoclonal antibody specific for tenascin-C. (2008)
  • Author(s): Odaka K., Uehara T., Arano Y., Adachi S., Tadokoro H., Yoshida K., Hasegawa H., Imanaka-Yoshida K., Yoshida T., Hiroe M., Irie T., Tanada S., Komuro I.
  • Journal Title: Int Heart J. 49 Pages: 481-92
• [Journal Article] Cerebrospinal fluid tenascin-C increases preceding the development of chronic shunt-dependent hydrocephalus after subarachnoid hemorrhage. (2008)
  • Author(s): Suzuki H., Kinoshita N., Imanaka-Yoshida K., Yoshida T., Taki W.
  • Journal Title: Stroke. 39 Pages: 1610-2
• [Presentation] Tenascin-C Is a Molecular Shock-Absorber That Protects Aorta from Dissection (2010)
  • Author(s): Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • Organizer: American Society for Cell Biology Annual Meeting 2010
  • Place of Presentation: Philadelphia, PA, USA.
  • Year and Date: 20101211-20101215
• [Presentation] ヒト大動脈瘤組織におけるマトリクス・メタロプロテアーゼ系の発現パターン解析 (2010)
  • Author(s): 西原通秀、青木浩樹、大野聡子、今泉勉
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡市
  • Year and Date: 20101015-20101017
• [Presentation] JAK/STAT系による大動脈瘤のサイトカインネットワーク制御 (2010)
  • Author(s): 大野聡子、青木浩樹、西原通秀、今泉勉
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡市
  • Year and Date: 20101015-20101017
• [Presentation] Tenascin-C Protects Aortic Tissue from The Development of Aortic Dissection (2010)
  • Author(s): Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • Organizer: Cell Symposia : Cell Inflammation and Disease Symposium
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 20100926-20100928
• [Presentation] Tenascin-C may regulate recruitment of mural cells during coronary arterial development. (2010)
  • Author(s): Imanaka-Yoshida K, Ando K., Yamagishi T, Yoshida T, Nakajima Y, Miyagawa-Tomita S
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Amsterdam, The Nederlands
  • Year and Date: 20100520-20100522
• [Presentation] シンポジウム「大動脈疾患治療UP to DATE」Molecular Network of Abdominal Aortic Aneurysm (2010)
  • Author(s): Aoki H, Yoshimura K, Kimura T, Imanaka-Yoshida K, Aonuma K, Hiroe M, Shigematsu H, Matsuzaki M, Imaizumi T
  • Organizer: 第74回日で撮器学会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] A Novel Hybrid Device for Personalized and Minimally Invasive Treatment of Aortic Aneurysms (2010)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Matsuzaki M, Hamano K
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Tenascin-C Protects Aortic Tissue From Multiple Insults Against The Development of Aortic Aneurysm (2010)
  • Author(s): Kimura T, Yoshimura K, Aoki H, Ikeda Y, Imanaka-Yoshida K, Hiroe M, Imaizumi T, Aonuma K, Matsuzaki M
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] シンポジウム「大動脈疾患治療UP to DATE」Molecular Network of Abdominal Aortic Aneurysm (2010)
  • Author(s): Aoki H, Yoshimura K, Kimura T, Imanaka-Yoshida K, Aonuma K, Hiroe M, Shigematsu H, Matsuzaki M, Imaizumi T
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 京都
  • Year and Date: 20100305-20100307
• [Presentation] Cardiovascular Development and Repair. Tenascin C as a Target for Regulation of Cardiac Remodeling. (2010)
  • Author(s): 今中一吉田恭子
  • Organizer: Keystone Symposia
  • Place of Presentation: Keystone, Colorado, アメリカ合衆国
  • Year and Date: 20100228-20100305
• [Presentation] シンポジウム14新規疾患関連分子Molecular network for the homeostasis of aortic tissue (2010)
  • Author(s): Aoki H, Kimura T, Yoshimura K, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • Organizer: 第18回日本血管生物医学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-03
• [Presentation] ワークショップ「慢性炎症:生活習慣病・癌に共通する基盤病態」炎症のタイムカプセル:大動脈瘤をモデル疾患とした慢性炎症の病態解明 (2009)
  • Author(s): 青木浩樹,吉村耕一,木村泰三,宮本貴宣,今中一吉田恭子,吉田利通,浜本義彦,青沼和隆,廣江道昭,重松宏,松崎益徳,今泉勉
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-20091212
• [Presentation] Tenascin C Protects Aortic Tissue From Multiple Insults Against The Development of Aortic Aneurysm (2009)
  • Author(s): Kimura T, Yoshimura K, Aoki H, Imanaka-Yoshida K, Yoshida T, Aonuma K, Hiroe M, Imaizumi T, Matsuzaki M
  • Organizer: American Society for Cell Biology Annual Meeting 2009
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20091205-20091209
• [Presentation] Tenascin C regulates recruitment of smooth muscle cells during coronary arterial development. (2009)
  • Author(s): Ando K, Yamagishi T, Miyagawa-Tomita S, Imanaka-Yoshida K, Yoshida T, Nakajima Y
  • Organizer: American Society for Cell Biology Meeitng 49th Annual Meeting.
  • Place of Presentation: San Diego, California, アメリカ合衆国
  • Year and Date: 20091205-20091209
• [Presentation] Tenascin-C Has A Protective Role during The Development of Aortic Aneurysm (2009)
  • Author(s): Kimura T, Yoshimura K, Aoki H, Ikeda Y, Hamano K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Aonuma K, Matsuzaki M
  • Organizer: American Heart Association Scientific Sessions 2009
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 20091114-20091118
• [Presentation] 細胞外マトリクステネイシンCによる線維化・炎症・免疫反応の制御 (2009)
  • Author(s): 今中恭子、廣江道昭
  • Organizer: 第13回日本心不全学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20091030-20091101
• [Presentation] Critical role of JNK2 for development of abdominal aortic aneurysm in a murine model (2009)
  • Author(s): Koichi Yoshimura, Hiroki Aoki, Akira Furutani, Masunori Matsuzaki, Kimikazu Hamano, Yoshimura K, Aoki H, Furutani A, Matsuzaki M, HHamano K
  • Organizer: Asian Society for Vascular Surgery Annual Congress 2009
  • Place of Presentation: Busan, Korea
  • Year and Date: 20091014-20091017
• [Presentation] Symposium "Recent advances in pathobiology and treatment of aortic aneurysms" Molecular Pathogenesis of Abdominal Aortic Aneurysm. (2009)
  • Author(s): Aoki H. Yoshimura H. Shigematsu T. Imaizumi M. Matsuzaki
  • Organizer: 第41回回日本動脈硬化学会
  • Place of Presentation: 下関
  • Year and Date: 20090717-20090718
• [Presentation] シンポジウム「大動脈疾患の新しい診断と治療」Stage-Specific Molecular Therapy for Abdominal Aortic Aneurysm:病態解明への挑戦 (2009)
  • Author(s): 青木浩樹
  • Organizer: 第73回日本循環器学会
  • Place of Presentation: Osaka,Japan
  • Year and Date: 20090320-20090322
• [Presentation] Tenascin-C may accelerate adverse cardiac remodeling and cardiac failure. (2008)
  • Author(s): Yoshida T, Nagaharu K, Imanaka-Yoshida K,Imanaka-Yoshida K, Nishioka T, Nagano Y, Onishi K, Yoshida T
  • Organizer: The American Society for Cell Biology 48^<th> Annual Meeting
  • Place of Presentation: San Francisco CA, アメリカ合衆国
  • Year and Date: 20081213-20081217
• [Presentation] The Vascular Smooth Muscle Cell-Autonomous Role of Id2 in Phenotypic Modulation In Vitro And Atherogenesis In Vivo (2008)
  • Author(s): Aoki H, Yoshimura K, Ikeda Y, Matsuzaki M
  • Organizer: The American Heart Association Scientific Sessions 2008
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20081108-20081112
• [Presentation] Protective Role of Tenascin-C during The Development of Aortic Aneurysm in Mice (2008)
  • Author(s): Kimura K, Yoshimura K, Aoki H, Ikeda Y, Imanaka-Yoshida K, Yoshida T, Hiroe M, Aonuma K, Matsuzaki M
  • Organizer: 2008 Stanford AAA Summit : Strategies for Multidisciplinary Research
  • Place of Presentation: Stanford, CA, USA
  • Year and Date: 20080904-20080905
• [Presentation] Incremental value of tenascin-C and BNP levels for predicting prognosis in patients with dilated cardiomyopathy and decompensated heart failure. (2008)
  • Author(s): Hiroe M, Onishi K, Fujimoto N, Sato A, Yoshida T, Imanaka-Yoshida K
  • Organizer: Basic Cardiovascular Science Conference 2008
  • Place of Presentation: Keystone Colorado, アメリカ合衆国
  • Year and Date: 20080628-20080631
• [Presentation] Tenascin-C may play a significant role in maturation of coronary arteries in mouse. (2008)
  • Author(s): 今中一吉田恭子
  • Organizer: Weinstein Cardiovascular Development Conference
  • Place of Presentation: Houston, Texas, アメリカ合衆国
  • Year and Date: 20080515-20080517