2010 Fiscal Year Final Research Report
脂肪肝グラフト部分肝移植における機能不全の解明と統合的治療法の開発
| Project/Area Number |
20390359
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHIMADA Mitsuo The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (10216070)
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| Co-Investigator(Kenkyū-buntansha) |
YASUTOMO Koji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30333511)
TANAKA Shinji 東京医科歯科大学, 情報処理センター, 科学技術振興特別特認准教授 (30253420)
NAKAMURA Takanori 香川大学, 医学部, 教授 (70183887)
IMURA Satoru 徳島大学, 病院, 助教 (90380021)
MORINE Yuji 徳島大学, 病院, 助教 (60398021)
TAKEDA Eiji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00144973)
UTSUNOMIYA Toru 徳島大学, 病院, 講師 (30304801)
IKEMOTO Tetsuya 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (20398019)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肝不全 / 肝移植 / 脂肪肝 / 肝虚血再灌流傷害 |
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| Research Abstract |
The majority of liver transplantation in Japan is living donor liver transplantation. As proportion of metabolic syndrome has recently been increasing, fatty liver of a candidate of donor has become a problem. We developed an animal model of non-alcoholic fatty liver (NAFL) disease, and gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the NAFL model. We obtained several novel findings regarding the mechanisms, by which NAFL induced liver functional insufficiency. We also found some possible therapeutic agents and strategies, which may improve the liver dysfunction and may support liver regeneration in these animal models.
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