2010 Fiscal Year Final Research Report
Identification and clinical application of colon cancer-specific gamma-secretase-targeting molecules
| Project/Area Number |
20390361
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMAGUCHI Kouji Kyushu University, 大学院・医学研究院, 共同研究員 (50191226)
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| Co-Investigator(Kenkyū-buntansha) |
KATANO Mitsuo 九州大学, 大学院・医学研究院, 教授 (10145203)
NAKAMURA Masafumi 九州大学, 大学病院, 講師 (30372741)
MORISAKI Takashi 九州大学, 大学院・医学研究院, 共同研究員 (90291517)
ONISHI Hideya 九州大学, 大学院・医学研究院, 准教授 (30553276)
SATOH Norihiro 九州大学, 大学院・医学研究院, 助教 (20423527)
KOJIMA Masayuki 九州大学, 大学病院, 助教 (90380394)
KUBO Makoto 九州大学, 大学病院, 助教 (60403961)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 大腸癌 / 膵癌 / gamma secretase (GS)複合体 / GS 阻害剤 / Taxane / アポトーシス / 分子標的治療 / 細胞周期 |
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| Research Abstract |
We showed for the first time that gamma secretase (GS) complexes regulate the response of colon and pancreatic cancer cells to taxanes through GS-dependent and GS-independent mechanisms. GS-dependent pathway is independent of Notch signaling. Interestingly, it was strongly indicated that GS complexes regulate the cell cycle progression of these cells in a GS-independent manner. Data suggest that GS complexes could be a new therapeutic target for overcoming resistance to taxanes in these cancers.
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[Journal Article] A protein-bound polysaccharide, PSK, enhances tumor suppression induced by docetaxel in a gastric cancer xenograft model.2009
Author(s)
Yamasaki A, Shoda M, Iijima H, Nagai S, Wada J, Suzuki H, Chikazawa N, Tasaka T, Kameda C, Tanaka H, Ikebe M, Jo E, Sato N, Nakamura M, Sekine F, Morisaki T, Katano M
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Journal Title
Anticancer Res 29
Pages: 843-850
Peer Reviewed
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