2010 Fiscal Year Final Research Report
Identification of molecular targets for lung adenocarcinoma treatment through proteome analysis of phospholyrated kinases
| Project/Area Number |
20390363
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
SAKURADA Akira Tohoku University, 病院, 助教 (60360872)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Chiaki 東北大学, 病院, 講師 (80333813)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺癌 / EGFR遺伝子 / キナーゼ / プロテオーム / リン酸化 |
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| Research Abstract |
Phospholyration of protein is important in signal transduction. We screened phospholyrated proteins in lung adenocarcinoma cell by using mass spectrometry to identify molecular targets for lung cancer treatment. Some proteins, including GFRF1/p190 A RhoGAP, were strongly controlled by EGFR protein. Functional analysis revealed that GFRF1/p190 A RhoGAP protein controls lung cancer cell proliferation through regulating MEK/ERK pathway. This protein could be a candidate of molecular treatment of lung adenocarcinoma.
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