2010 Fiscal Year Final Research Report
Pharmacological control of soluble tissue factor and monocyte for the inhibition of the extrinsic coagulation pathway during cardiopulmonary bypass in monkeys
| Project/Area Number |
20390364
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HIRAMATSU Yuji University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (30302417)
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| Co-Investigator(Kenkyū-buntansha) |
AGEYAMA Naohide 独立行政法人医薬基盤研究所センター, 霊長類医科学, 主任研究員 (50399458)
SAKAKIBARA Yuzuru 筑波大学, 大学院・人間総合科学研究科, 教授 (60192085)
HASEGAWA Yuichi 筑波大学, 大学院・人間総合科学研究科, 准教授 (00251059)
TOKUNAGA Chiho 筑波大学, 大学院・人間総合科学研究科, 講師 (30451701)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心臓大血管外科学 / 体外循環 / 外因系凝固 / TFPI / PDE IV阻害薬 / ヘパリン |
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| Research Abstract |
Administration of high-dose heparin causes massive release of TFPI from vascular endothelial cells. We purposed to provide evidence to clarify the role of TFPI (with or without PDE IV inhibitor) in attenuation of TF-dependent thrombin generation during primate CPB. In the primate CPB model, plasma TFPI was enhanced by pre-heparinization, and levels of thrombin generation were reduced by inhibition of extrinsic pathway when compared with control group. PDE IV inhibitor reduced monocyte function and thrombin generation. Massive release of plasma TFPI induced by early heparin administration may attenuate TF-dependent thrombin generation during clinical CPB.
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