2010 Fiscal Year Final Research Report
Combining and purification of F^<18>-acetate for diagnosis of lung adenocarcinoma with positron emission tomography
| Project/Area Number |
20390372
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
NOMORI Hiroaki Kumamoto University, 医学部, 教授 (90146613)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺癌 / PET / 腺癌 / 胸腺癌 / 酢酸 / ^<11>C / ^<18>F |
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| Research Abstract |
We already demonstrated that the slow growing well-differentiated adenocarcinomas of the lung showed false-negative for FDG-PET, while they frequently showed positive for ^<11>C-acetate. However, because ^<11>C has short half-life period, i.e. 20min, we have combined the ^<18>F-acetate to investigate the possibility for clinical use. As a result, the ^<18>F-acetate was not accumulated in any organs and was excreted in urine, of which disposition was completely different from ^<11>C-acetate, which usually showed the accumulation in pancreas and liver. Therefore, ^<18>F-acetate cannot be used as an analogue of ^<11>C-acetate as a tracer of PET scanning. As the other experiment, we evaluated the ^<11>C-acetate-PET for thymomas, which are also slow growing tumors as well as well-differentiated adenocarcinoma of the lung. As a result, we have found that the histological type of thymoma could be predicted by accumulations of ^<11>C-acetate and ^<18>F-FDG.
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Research Products
(8 results)
