2010 Fiscal Year Final Research Report
Clinical and translational evaluation of circulating tumor cells and circulating endothelial cells in lung cancer
| Project/Area Number |
20390374
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
TANAKA Fumihiro Hyogo College of Medicine, 医学部, 教授 (10283673)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Nobuyuki 兵庫医科大学, 医学部, 講師 (50402889)
OKUMURA Yoshitomo 兵庫医科大学, 医学部, 助教 (30388813)
TAKUWA Teruhisa 兵庫医科大学, 医学部, 助教 (00412049)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺癌 / 循環腫瘍細胞 / 循環内皮細胞 |
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| Research Abstract |
Prognosis of primary lung cancer patients is not satisfactory, which is mostly caused by frequent development of distant metastasis. We tried to detect circulating tumor cells (CTCs) that circulate in the peripheral blood, because CTC is a marker of distant metastasis. As a result, we revealed that CTCs were detected in about 30% of lung cancer patients, and that the number of CTCs was useful marker in the diagnosis and evaluation of tumor progression. Moreover, we evaluated circulating endothelial cells (CECs), which represent tumor angiogenesis essential for tumor progression, and revealed that CEC-count might be also useful in the diagnosis of lung cancer.
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