2010 Fiscal Year Final Research Report
Convection-enhanced delivery of ACNU with systemic administration of temozolomide
| Project/Area Number |
20390378
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
SONODA Yukihiko Tohoku University, 大学院・医学系研究科, 非常勤講師 (90302140)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Yoji 宮城県がんセンター研究所, 特任研究員 (30420045)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 膠芽腫 / MGMT CED法 / 薬剤耐性 |
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| Research Abstract |
This study evaluated the efficacy of combined-modality treatments using CED of ACNU with systemic administration of temozolomide. CED of ACNU plus systemic administration of temozolomide significantly enhanced survival rate compared with each treatment alone (versus CED : p<0.001, versus systemic temozolomide : p<0.05). Multimodality treatment using CED of ACNU and systemic chemotherapy with temozolomide is a promising strategy for treatment of brain tumors.
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