Bidirectional approach with neurotrophic factors for the acceleration of neuro-regeneration.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390411
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Gunma University
• Principal Investigator: SAITO Shigeru Gunma University, 大学院・医学系研究科, 教授 (40251110)
• Co-Investigator(Kenkyū-buntansha): OGINO Yuichi 群馬大学, 医学部, 助教 (20420094) ; TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
• Project Period (FY): 2008 – 2010
• Keywords: 疼痛管理学 / 再生医学 / 栄養因子

Research Abstract

For the better recovery of damaged neurons, cellular environment seems to be crucial. In the present study, the authors assessed effects of neurotrophic factors in various settings. As the results, it was revealed that normo-glycemia is the best condition for the neuro-regeneration. Newly developed drug delivery system was identified as effective for gradual release of nerve activity controlling drugs.

Research Products

• [Journal Article] Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats. (2010)
  • Author(s): Obata H, Sakurazawa S, Kimura M, Saito S
  • Journal Title: Brain Res. 1363 Pages: 72-80
  • Peer Reviewed
• [Journal Article] Technical communication : percutaneous radiofrequency mandibular nerve rhizotomy guided by high-speed real-time computed tomography fluoroscopy. (2010)
  • Author(s): Koizuka S, Saito S, Tobe M, Sekimoto K, Obata H, Koyama Y
  • Journal Title: Anesth Analg. 111(3) Pages: 763-7
  • Peer Reviewed
• [Journal Article] Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats. (2010)
  • Author(s): Obata H, Kimura M, Nakajima K, Tobe M, Nishikawa K, Saito S
  • Journal Title: J Pharmacol Exp Ther. 334(3) Pages: 1059-65
  • Peer Reviewed
• [Journal Article] Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model : comparison with a neuropathic pain model. (2009)
  • Author(s): Ito N, Obata H, Saito S
  • Journal Title: Anesthesiology. 111(3) Pages: 640-8
  • Peer Reviewed
• [Journal Article] The radiobiological effectiveness of carbon-ion beams on growing neurons. (2009)
  • Author(s): Al-Jahdari WS, Suzuki Y, Yoshida Y, Hamada N, Shirai K, Noda SE, Funayama T, Sakashita T, Kobayashi Y, Saito S, Goto F, Nakano T
  • Journal Title: Int J Radiat Biol. 85(8) Pages: 700-9
  • Peer Reviewed
• [Journal Article] The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats. (2009)
  • Author(s): Nakajima K, Obata H, Ito N, Goto F, Saito S
  • Journal Title: Eur J Pain. 13(5) Pages: 441-7
  • Peer Reviewed
• [Journal Article] A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain. (2008)
  • Author(s): Ito N, Saito S, Yamada MH, Koizuka S, Obata H, Nishikawa K, Tabata Y
  • Journal Title: J Anesth. 22(4) Pages: 449-52
  • Peer Reviewed
• [Presentation] Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative pain (2010)
  • Author(s): 木村雅文
  • Organizer: Society for Neuroscience Annual Meeting 2010
  • Year and Date: 2010-11-14
• [Presentation] 塩酸トラマドールの鎮痛作用機序-ラット術後痛モデルとマイクロダイアリシスでの検討- (2010)
  • Author(s): 木村雅文
  • Organizer: 第32回日本疼痛学会
  • Year and Date: 2010-07-03
• [Presentation] ミルナシプランおよびパロキセチンの鎮痛メカニズム (2010)
  • Author(s): 中島邦枝
  • Organizer: 日本麻酔科学会第57回学術集会
  • Year and Date: 2010-06-04
• [Book] CTガイド下神経ブロック (2011)
  • Author(s): 齋藤繁,他
  • Total Pages: 50-56, 123-127, 138-143, 166-167
  • Publisher: 真興交易(株)医書出版部