2010 Fiscal Year Final Research Report
Genetic analysis of prostate cancer susceptibility performing genomewide homozygosity haplotype analysis
| Project/Area Number |
20390419
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
SUZUKI Kazuhiro Gunma University, 大学院・医学系研究科, 教授 (80312891)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Kazuto 群馬大学, 大学院・医学系研究科, 准教授 (00302472)
MATSUI Hiroshi 群馬大学, 大学院・医学系研究科, 助教 (40450374)
KOIKE Hikdekazu 群馬大学, 医学部, 助教 (90420091)
HAGIWARA Koichi 埼玉医科大学, 医学部, 教授 (00240705)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 前立腺癌 / 遺伝子解析 / スクアレン合成酵素 / FDFT1 |
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| Research Abstract |
We analyzed the genomic DNA using genomewide homozyosity haplotype analysis to identify the susceptibility gene for familial/hereditary prostate cancer. Through previous studies and the present study, we found the significant association of prostate cancer risk with the gene encoding squalene synthase, i.e., farnesyldiphosphate farnesyltrasfrerase (FDFT1). The AA+AG genotypes of SNP in the promoter region, rs2645429 was found significantly in patients with cases. Functional analysis of FDFT1 showed the elevation of promoter activity in the A type promoter, and that the squalene synthase has close relations to prostate cancer growth.
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