2010 Fiscal Year Final Research Report
Pathophysiology of unexplained recurrent pregnancy loss, preterm labor and preeclampsia from the viewpoint of reproductive immunology
| Project/Area Number |
20390431
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
SAITO Shigeru University of Toyama, 大学院・医学薬学研究部, 教授 (30175351)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Akitoshi 富山大学, 大学院・医学薬学研究部, 助教 (00436792)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 制御性T細胞 / 妊娠 / 着床不全 / 流産 / 早産 / 妊娠高血圧腎症 |
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| Research Abstract |
T-helper (Th) cells play a central role in modulating immune responses. We discuss the pathophysiology of unexplained recurrent pregnancy loss, preterm labor and preeclampsia from the viewpoint of new Th1/Th2/Th17 and regulatory T (Treg) cell paradigm. We have reported that Treg cells play an essential role for maintenance of allogeneic pregnancy in early pregnancy, but not in late pregnancy. We also found that paternal antigen-specific Treg cells increase in uterine draining lymphonodes before the implantation and in uterus after implantation. We have found NKreg cells increase in the pregnant uterus and they express CD25 on their surface. They produce immunosuppressive cytokines such as IL-10 and TGFβ. Th17 cells increased in the uterus of preterm labor cases with severe chorioamnionitis and of spontaneous abortion cases in late stage, and there were significant positive correlation between Th17 cells number and neutrophil number. IL-17 also augment the TNF-α-induced IL-8 secretion by amniotic mesenchymal cells in a dose dependent manner. In preeclampsia, we found the production of VEGF and Galectin-1 by peripheral blood-T cells and -NK cells was decreased suggesting that angiogenesis and tolerance induction systems are dysregulated in preeclampsia.
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[Journal Article] A role for IL-17 in induction of an inflammation at fetomaternal interface in preterm labour.2010
Author(s)
Ito M., Nakashima A., Hidaka T., Okabe M., Bac N.D., Ina S., Yoneda S., Shiozaki A., Sumi S., Tsuneyama K., Nikaido T., Saito S.
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Journal Title
J.Reprod Immunol. 84
Pages: 75-85
Peer Reviewed
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[Journal Article] ワークショップ12「不育症の新たな原因探索と治療」本邦における不育症のリスク因子とその予後に関する研究2009
Author(s)
齋藤滋, 杉浦真弓, 田中忠夫, 藤井知行, 杉俊隆, 丸山哲夫, 竹下俊行, 山田秀人, 小澤伸晃, 木村正, 山本樹生, 藤井俊策, 中塚幹也, 下屋浩一郎
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Journal Title
日本周産期・新生児医学会雑誌 45
Pages: 1144-1148
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[Journal Article] Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia.
Author(s)
Molvarec A, Blois M S, Stenczer B, Toldi G, Tirado-Gonzalez I, Ito M, Shima T, Yoneda S, Vasarhelyi B, Rigo J., Saito S.
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Peer Reviewed
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