2010 Fiscal Year Final Research Report
Study on the mechanism of the age-related hearing loss and establishment of its preventive treatment
| Project/Area Number |
20390440
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMASOBA TATSUYA The University of Tokyo, 医学部附属病院, 教授 (60251302)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Kenji 東京大学, 医学部附属病院, 講師 (40334370)
SAKAMOTO Takashi 東京大学, 医学部附属病院, 講師 (50323548)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 老化 / 蝸牛 / ミトコンドリア / アポトーシス / 難聴 / 酸化ストレス |
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| Research Abstract |
Deficiency of vitamin C accelerated presbyacusis (ARHL), whereas supplementation of vitamin C did not attenuate ARHL in C57BL/6 mice. The onset of ARHL was delayed when catalase was over-expressed in mitochondria in C57BL/6 mice. Such attenuation of ARHL was also observed when C57BL/6 mice were given alpha-lipoic acid, CoQ10, or NAC. Expression of Bak significantly decreased in the cochleae of the mice showing attenuation of ARHL. ARHL was significantly attenuated in Bak-deficient mice, but not in Bax-deficient mice. These findings suggest that chronic oxidative stress induced Bak-dependent apoptosis in the cochlear cells, resulting in the development of ARHL.
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Research Products
(19 results)
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[Journal Article] Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.2009
Author(s)
Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA
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Journal Title
Proc Natl Acad Sci USA. 106
Pages: 19432-19437
Peer Reviewed
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