Study of vitreous body : Analysis of microenvironmental control and development of novel treatment.

2011 Fiscal Year Final Research Report

• Project/Area Number: 20390450
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kagoshima University
• Principal Investigator: SAKAMOTO Taiji 鹿児島大学, 医歯学総合研究科, 教授 (10235179)
• Co-Investigator(Kenkyū-buntansha): SONODA Koh-hei 山口大学, 医学系・研究科, 教授 (10294943) ; MARUYAMA Ikuro 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282) ; TAKAO Sonshin 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (80171411) ; KOSAI Ken-ichiro 鹿児島大学, 医歯学総合研究科, 教授 (90258418) ; SUDA Yasuo 鹿児島大学, 理工学部・研究科, 教授 (70179282)
• Project Period (FY): 2008 – 2011
• Keywords: 硝子体細胞 / SDF-1 / 硝子体免疫 / 薬物治療 / 超音波

Research Abstract

We performed the study of vitreoretinal diseases from the points of its pathogenesis, molecular mechanism, and treatment. First, the relationship between intravitreous damage-associated molecular pattern and retinal damage was analyzed. As a result, retinal pathology was strongly affected not only by bioactive molecules such as cytokines, but rather by damaged cells and its related proteins. The experimental treatment using KO animals was very effective. The present findings are quite beneficial for developing a new treatment with minimal tissue damage.

Research Products

• [Journal Article] 急速に失明に至り,特異な対光反射を示した悪性腫瘍随伴網膜症 (2011)
  • Author(s): 尾辻太, 精松徳子, 中尾久美子, 坂本泰二
  • Journal Title: 日本眼科学会雑誌 Volume: 115(10) Pages: 924-929
  • Peer Reviewed
• [Journal Article] Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis : A novel antiangiogenic therapy (2011)
  • Author(s): Kamisasanuki T, Tokushige S, Terasaki H, Khai NC, Wang Y, Sakamoto T, Kosai K.
  • Journal Title: Biochem Biophys Res Commun Volume: 413(1) Pages: 128-135
  • URL: http://dx.doi.org/10.1016/j.bbrc.2011.08.068
  • Peer Reviewed
• [Journal Article] NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway (2011)
  • Author(s): Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I, Sakamoto T.
  • Journal Title: Lab Invest Volume: 91(9) Pages: 1277-1290
  • DOI: doi:10.1038/labinvest.2011.101.
  • Peer Reviewed
• [Journal Article] A case of intraocular lymphoma having retinal adverse events associated with intravitreal methotrexate (2011)
  • Author(s): Kuroiwa N, Abematsu N, Matsuo Y, Nakao K, Sakamoto T.
  • Journal Title: Nihon Ganka Gakkai Zasshi Volume: 115(7) Pages: 611-616
  • Peer Reviewed
• [Journal Article] Japanese Retina and Vitreous Society Triamcinolone Survey Group (2011)
  • Author(s): Sakamoto T, Ishibashi T, Ogura Y, Shiraga F, Takeuchi S, Yamashita H
  • Journal Title: Nihon Ganka Gakkai Zasshi Volume: 115(6) Pages: 523-8
  • Peer Reviewed
• [Journal Article] Visual outcome after intravitreal triamcinolone acetonide depends on optical coherence tomographic patterns in patients with diffuse diabetic macular edema (2011)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Hirano Y, Sakamoto T, Ogura Y, Shiono T.
  • Journal Title: Retin Volume: 31(4) Pages: 748-754
  • DOI: DOI:10.1097/IAE.0b013e3181f04991
  • Peer Reviewed
• [Journal Article] Ocular surface molecule after transconjunctival vitrectomy (2011)
  • Author(s): Fujita A, Uchino E, Otsuka H, Arimura N, Noda N, Ishibashi T, Sakamoto T.
  • Journal Title: Br J Ophthalmol Volume: 95(3) Pages: 419-423
  • Peer Reviewed
• [Journal Article] Incidence of outer foveal defect after macular hole surgery (2011)
  • Author(s): Kawano H, Uemura A, Sakamoto T.
  • Journal Title: Am J Ophthalmol Volume: 151(2) Pages: 31-322
  • URL: http://dx.doi.org/10.1016/j.ajo.2010.08.034
  • Peer Reviewed
• [Journal Article] Hyalocytes : Essential cells of the vitreous cavity in vitreoretinal pathophysiology (2011)
  • Author(s): Sakamoto T. Ishibashi T.
  • Journal Title: Retina Volume: 31(2) Pages: 222-228
  • DOI: DOI:10.1097/IAE.0b013e3181facfa9
  • Peer Reviewed
• [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment (2010)
  • Author(s): Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T.
  • Journal Title: Am J Pathol Volume: 177(5) Pages: 2268-2277
  • DOI: DOI:10.2353/ajpath.2010.100134
  • Peer Reviewed
• [Journal Article] Combination therapy for retinal vein occlusion (2010)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Takeshita T, Shiono T, Sakamoto T.
  • Journal Title: Ophthalmology Volume: 117(9) Pages: e1-3
  • URL: http://dx.doi.org/10.1016/j.ophtha.2010.03.077
  • Peer Reviewed
• [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment (2009)
  • Author(s): Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
  • Journal Title: Lab Invest Volume: 89(3) Pages: 278-289
  • DOI: DOI:038/labinvest.2008.165
  • Peer Reviewed
• [Journal Article] Posturing time after macular hole surgery modified by optical coherence tomography images : a pilot study (2009)
  • Author(s): Masuyama K, Yamakiri K, Arimura N, Sonoda Y, Doi N, Sakamoto T.
  • Journal Title: Am J Ophthalmol Volume: 147(3) Pages: 481-488
  • URL: http://dx.doi.org/10.1016/j.ajo.2008.09.028
  • Peer Reviewed
• [Presentation] ポリープ状脈絡膜血管症における動静脈交差部の血管拍動 (2011)
  • Author(s): 大久保明子, 鮫島宗文, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 小児の裂孔原性網膜剥離に対する強膜内陥術の術後屈折変化 (2011)
  • Author(s): 寺崎寛人, 山切啓太, 山下高明, 土居範仁, 上村昭典, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 硝子体出血における血管内皮細胞増殖因子についての検討 (2011)
  • Author(s): 白澤誠, 有村昇, 大塚寛樹, 園田祥三, 橋口照人, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 大型黄斑円孔へのinverted internal limiting membrane(ILM) flap technique手術 (2011)
  • Author(s): 山下敏史, 川野浩輝, 川野純廣, 園田恭志, 山切啓太, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] 中心性漿液性脈絡網膜症に対する低照射容量PDTの検討 (2011)
  • Author(s): 園田祥三, 大塚寛樹, 白澤誠, 有村昇, 上笹貫太郎, 喜井裕哉, 大久保明子, 坂本泰二
  • Organizer: TEAM2011
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-12-02
• [Presentation] The subfoveal choroidal thickness in Japanese young normal eyes (2011)
  • Author(s): Takehiro Yamashita, Toshifumi Yamashita, Minoru Tanaka, Yuya Kii, Kumiko Nakao, Taiji Sakamoto
  • Organizer: The 4^<th> joint meeting of Korea-China-JapanOphthalmologists
  • Place of Presentation: Seoul Korea
  • Year and Date: 2011-11-04
• [Presentation] 小児増殖硝子体網膜症の2症例に対するヘビーシリコーンオイルの使用経験 (2011)
  • Author(s): 藤原悠子, 山切啓太, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-09
• [Presentation] 新しい眼圧計(DCT)で測定した正常眼圧の分布 (2011)
  • Author(s): 伊東健, 田原昭彦, 渡部晃久, 久保田敏昭, 池田康博, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] 翼状片手術における術中マイトマイシンC塗布の角膜内皮細胞への影響 (2011)
  • Author(s): 内野英輔, 藤田敦子, 精松泰子, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] NSAIDs点眼による脈絡膜血管新生抑制 (2011)
  • Author(s): 吉永就正, 有村昇, 大塚寛樹, 竹之内和則, 貞村ゆかり, 野間聖, 川原幸一, 園田祥三, 橋口照人, 丸山征郎, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-08
• [Presentation] 外傷性角膜炎に続発した真菌性虹彩肉芽腫の1例 (2011)
  • Author(s): 藤田敦子, 田上純眞, 精松泰子, 内野英輔, 坂本泰二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-10-07
• [Presentation] 乳頭黄斑角と視神経乳頭周囲網膜神経線維層最厚部の関連 (2011)
  • Author(s): 田中実, 山下高明, 喜井裕哉, 中尾久美子, 坂本泰二
  • Organizer: 第22回日本緑内障学会
  • Place of Presentation: 秋田ビューホテル・アトリオン(秋田市)
  • Year and Date: 2011-09-24
• [Presentation] 視神経乳頭周囲網膜神経線維層厚における最厚部の近視性変化 (2011)
  • Author(s): 山下高明, 田中実, 喜井裕哉, 中尾久美子, 坂本泰二
  • Organizer: 第22回日本緑内障学会
  • Place of Presentation: 秋田ビューホテル・アトリオン(秋田市)
  • Year and Date: 2011-09-23
• [Presentation] Optic disc swelling in Vogt-Koyanagi-Harada disease (2011)
  • Author(s): Nakao K, Abematsu N, Mizushima Y, Sakamoto T.
  • Organizer: Joint Congress of SOE/AAO
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2011-06-04
• [Presentation] 黒色細胞腫に伴う網膜下新生血管に対しベバシズマブ硝子体注射が奏功した1例 (2011)
  • Author(s): 上笹貫太郎, 大塚寛樹, 喜井裕哉, 園田祥三, 坂本泰二
  • Organizer: 第81回九州眼科学会
  • Place of Presentation: 沖縄県市町村自治会館(那覇市)
  • Year and Date: 2011-05-28
• [Presentation] 強膜トンネル併用円蓋部基底線維柱帯切除術単独と白内障手術併用の術後成績の検討 (2011)
  • Author(s): 田中実, 喜井裕哉, 山下高明, 坂本泰二
  • Organizer: 第81回九州眼科学会
  • Place of Presentation: 沖縄県市町村自治会館(那覇市)
  • Year and Date: 2011-05-27
• [Presentation] 角膜内皮移植術後に発症したサイトメガロウィルス角膜内皮炎の一例 (2011)
  • Author(s): 内野英輔, 園田祥三, 藤田敦子, 精松泰子, 坂本泰二
  • Organizer: 第81回九州眼科学会
  • Place of Presentation: 沖縄県市町村自治会館(那覇市)
  • Year and Date: 2011-05-27
• [Presentation] Biology of hyalocytes, Special Invited Lecture, International Symposiu for New Inshight of Translational Research (2011)
  • Author(s): Sakamoto T.
  • Organizer: 2011 BOVRC and CRCID joint symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-05-21
• [Presentation] 黄斑円孔術後早期のうつ向き姿勢(Pr)解除時期決定の試み (2011)
  • Author(s): 山下敏史, 山切啓太, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-14
• [Presentation] 糖尿病網膜症と網膜静脈閉塞症における硝子体中VEGFとIL-6, IL-8の比率 (2011)
  • Author(s): 有村昇, 吉永就正, 大塚寛樹, 山切啓太, 園田恭志, 山下敏史, 園田祥三, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-13
• [Presentation] Transwell^<TM>を用いた極性ブタ網膜色素上皮細胞の培養 (2011)
  • Author(s): 園田祥三, 大塚寛樹, 白澤誠, 有村昇, 園田恭志, 坂本泰二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-12
• [Presentation] Non-infectious Endophthalmitis After Intravitreal Injection of Triamcinolone Acetonide (2011)
  • Author(s): Hiroki Otsuka, Noboru Arimura, Taro Kamisasanuki, Yukiko Matsuo, Futoshi Otsuji, Yasushi Sonoda, Keita Yamakiri, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-05
• [Presentation] Nsaids Eye Drop As Anti-oxidant Treatment In Choroidal Neovascularization (2011)
  • Author(s): Narimasa Yoshinaga, Noboru Arimura, Shozo Sonoda, Kazunori Takenouchi, Yukari Sadamura, Satoshi Noma, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-02
• [Presentation] Inhibition Of Choroidal Neovascularization By Targeting To Membrane Protein Cd9 (2011)
  • Author(s): Hiroto Terasaki, Taro Kamisasanuki, Ken-ichiro Kosai, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-01
• [Presentation] Long-term Intraocular Pressure After 20 Gauge Pars PlanaVitrectomy (2011)
  • Author(s): Takehiro Yamashita, Yuya Kii, Akinori Uemura, Taiji Sakamoto
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale・U. S. A
  • Year and Date: 2011-05-01
• [Presentation] Chromovitrectomy (2010)
  • Author(s): Sakamoto T.
  • Organizer: Rebert Burns lecture of Mason Eye Institute(Part 2), University of Missouri
  • Place of Presentation: Colombia, Missouri, USA
  • Year and Date: 2010-10-23
• [Presentation] Intravitreous mediators in diabetic retinopathy (2010)
  • Author(s): Sakamoto T.
  • Organizer: Sympsium. ARVO summer conference. NIH
  • Place of Presentation: Bethesda, USA
  • Year and Date: 2010-08-01
• [Presentation] CD9 as a therapeutic target of ocular diseases(invited speaker symposium) (2009)
  • Author(s): Samoto T, Kamisasanuki T, Kosai K.
  • Organizer: 8^<th> International symposium of ocular pharmacology and therapeutics
  • Place of Presentation: Rome Cavaliori, Rome, Italy
  • Year and Date: 2009-12-04
• [Presentation] Immediate change after intravitreous triamcinolone for diabetic macular edema. Invited lecture. Symposium of macular disorder (2009)
  • Author(s): Sakamoto T.
  • Organizer: 4^<th> Asia-Pacific Vitreo-Retinal Society
  • Place of Presentation: Grand Hotel, Taipei, Taiwan
  • Year and Date: 2009-11-11
• [Presentation] Intravitreous staining by triamcinolone during PPV. Symposium (2009)
  • Author(s): Sakamoto T.
  • Organizer: 107^<th> Deutche Ophthalmol
  • Place of Presentation: Gesellshaft. Leipzig Messe, Leipzig, Germany
  • Year and Date: 2009-09-26
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2011)
  • Inventor(s): 小戝健一郎、坂本泰二、上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: 特許、国内出願特願2011-510400
  • Filing Date: 2011-10-20
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2010)
  • Inventor(s): 小戝健一郎,坂本泰二,上笹貫太郎
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: 特許、国際出願PCT/JP2010/057735
  • Filing Date: 2010-04-23
  • Overseas