Functional analyses of novel cell membrane-associated protein in the intracellular molecular interaction during tooth germ morphogenesis.

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20390466
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Kyushu University
• Principal Investigator: SAKAI Hidetaka Kyushu University, 歯学研究院, 教授 (80136499)
• Project Period (FY): 2008 – 2011
• Keywords: 歯胚 / 発生・再生 / cDNAサブトラクション / in situ hybridization / 免疫組織化学 / アンチセンス法 / 器官培養 / 歯原性幹細胞

Research Abstract

発生過程のド顎骨のcDNAサブトラクションにより得られた遺伝子のうち、細胞膜に受容体として存在する蛋白に関連した新規遺伝子(Prtg)について、歯胚の発生過程における機能的役割を明らかにし、歯胚再生の足がかりを見いだす事を目的とする研究である。

Research Products

• [Journal Article] In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar. (2011)
  • Author(s): Jun-ya Honda, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Yukiko Ookuma, Hiroaki Fujiwara, Maho Shiotsuka, Ichiro Takahashi, Hidetaka Sakai
  • Journal Title: Journal of Molecular Histology 42 Pages: 83-90
• [Journal Article] In situ expression of 15kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar. (2010)
  • Author(s): Merina Akhter, Ieyoshi Kobayashi, Tamotsu Kiyoshima, Kengo Nagata, Hiroko Wada, Yukiko Ookuma, Hiroaki Fujiwara, Jyun-ya Honda, Hidetaka Sakai
  • Journal Title: Journal of Molecular Histology 41 Pages: 185-191
• [Journal Article] Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar. (2010)
  • Author(s): Keiko F Takahashi, Tamotsu Kiyoshima, Ieyoshi Kobayashi, Ming Xie, Haruyoshi Yamaza, Hiroaki Fujiwara, Yukiko Ookuma, Kengo Nagata, Hiroko Wada, Takako Sakai, Yoshihiro Terada, Hidetaka Sakai
  • Journal Title: BMC Developmental Biology 10 Pages: 115
• [Presentation] マウス歯胚形成過程におけるThymosinb10とThymosinb4との発現様式の比較検討 (2010)
  • Author(s): 和田裕子、清島保、小林家吉、塩塚真帆、永田健吾、大隈由紀子、藤原弘明、高橋一郎、坂井英隆
  • Organizer: 第52回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 東京
  • Year and Date: 20100920-20100922
• [Presentation] Functional implication of Thymosin beta 4 in the tooth development (2010)
  • Author(s): Y.OOKUMA, I.OBAYASHI, T.KIYOSHIMA, K.NAGATA, H.FUJIWARA, H.YAMAZA, K.NONAKA, H.SAKAI
  • Organizer: The 88th General Session & Exhibition of the IADR)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100714-20100717