2010 Fiscal Year Final Research Report
Inhibition of bone destruction by phosphatidylserine-containing liposomes based on t he regulation of phagocytes functions
Project/Area Number |
20390472
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional basic dentistry
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Research Institution | Kyushu University |
Principal Investigator |
HIROSHI Nakanishi Kyushu University, 大学院・歯学研究院, 教授 (20155774)
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Co-Investigator(Kenkyū-buntansha) |
TAKE Hiro 九州大学, 大学院・歯学研究院, 准教授 (10420598)
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Project Period (FY) |
2008 – 2010
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Keywords | リポソーム / 炎症性骨吸収 / 骨芽細胞 / 破骨細胞 / ホスファチジルセリン |
Research Abstract |
This study investigated the effects of phosphatidylserine-containing liposomes (PSLs) on the osteoclastogenesis. In the rat bone marrow culture system, osteoclast precursors phagocytosed PSLs to secrete TGF-β1and PGE2, which in turn inhibited osteoclastogenesis through the downregulation of receptor activator for NF-κB ligand, receptor activator of NF-κB. Consistent with these in vitro observations, i.m. injection of PSLs significantly increased the plasma level of TGF-β1 and PGE2 and decreased the expression of receptor activator for NF-κB ligand, receptor activator of NF-κB the skeletal tissues of ankle joints of rats with adjuvant arthritis. Together with the inhibitory effects on osteoclastogenes, PSLs are involved in regulation of bone remodeling. Because PS is a component of the cell membrane, PSLs therefore can be a potentially effective pharmacological intervention against abnormal bone loss, such as osteoporosis without deleterious side effects.
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[Journal Article] Reverse of brain aging by an overexpression of human mitochondrial transcription factor A in mice.2008
Author(s)
Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H.
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Journal Title
J.Neurosci. 28
Pages: 8624-8634
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[Remarks] ホームページ等 なし