2010 Fiscal Year Final Research Report
The study of the brain plasticity adapting to the changes of intraoral environment based on the brain molecules
| Project/Area Number |
20390486
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
WATANABE Makoto 東北大学, 大学院・歯学研究科, 客員教授 (80091768)
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| Co-Investigator(Kenkyū-buntansha) |
TSUBOI Akito 東北大学, 病院, 准教授 (00241646)
YAMAGUCHI Satoshi 東北大学, 病院, 助教 (50400263)
KIKUCHI Masahiko 東北大学, 病院, 教授 (60195211)
ITO Shintaro 東北大学, 大学院・歯学研究科, 非常勤講師 (00361105)
FUKUDA Hiroshi 東北大学, 加齢医学研究所, 教授 (30125645)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 可塑性 / 脳内分子 / PET |
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| Research Abstract |
The aim of the present study was to investigate the effects of different mastication on the dopaminergic system in the rat striatum using positron emission tomography (PET)and brain microdialysis (MD). Male F344 rats were fed solid diets (group-S)or powder diets (group-P). These rats were bred reach to 8 and 60 weeks old under the above conditions. As the result of PET study, the accumulation of 11C-RAC at 60 weeks old of group-S was lower than that of group-P. As the result of MD study, dopamine release at 8 and 60 weeks old of group-P was higher than that of group-S. These results suggest that the different mastication influenced on dopaminergic system at the molecular level.
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[Journal Article] 食と脳2009
Author(s)
渡邉誠, 坪井明人
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Journal Title
咀嚼と脳機能の賦活脳血流の視点から. 別冊the Quintessence臨床家のための矯正YEAR BOOK' 09症例から学ぶ矯正臨床のクリニカルヒント
Pages: 87-90
Peer Reviewed
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