Development of a light cured resin-BMP composite material intending to induce new bone formation in vivo

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390502
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: KAWAI Tatsushi 愛知学院大学, 歯学部, 教授 (60167351)
• Co-Investigator(Kenkyū-buntansha): TSURUTA Shozou 愛知学院大学, 歯学部, 准教授 (40183488) ; HAYASHI Tatsuhide 愛知学院大学, 歯学部, 講師 (70367621)
• Project Period (FY): 2008 – 2010
• Keywords: 生体材料 / 生物・生体工学 / 再生医療 / 光造形 / biomaterial / tissue engineering / biological engineering / 3D modeling

Research Abstract

In order to develop an implant material that has a potential to induce new bone formation adequate to the 3-dimentional shape that refrects to each clinical situation, a resin with BMP composite was assembled. According to the 3-Dimentional data obtaining from micro X-ray CT system, resin scaffold was made by means of 3D-SLS system, then combined with BMP. The composite material was implanted in vivo and new bone formation occurred surrounding tissue of the scaffold.

Research Products

• [Journal Article] Development of an orthodontic elastic material using EMA-based resin combined with 1-butanol (2011)
  • Author(s): Masuda, T., Miyazawa, K., Ueda, N., Hata, Y., Kawai, T., Goto, S
  • Journal Title: Dental Materials Journal Volume: 30(5) Pages: 664-671
• [Journal Article] Osteoanagenesis after transplantation of bone marrow-derived mesenchymal stem cells using polyvinylidene chloride film as a scaffold (2011)
  • Author(s): Hamajima, S., Hayashi, T., Sato, Y., Sasaki, K., Kawai, T
  • Journal Title: Dental Materials Journal Volume: 30(5) Pages: 707-716
• [Journal Article] Selected physical properties of a PEMA-based resin for possible use in a root canal filling material (2011)
  • Author(s): Wanibe, H., Yamamoto, M., Nakata, K., Kawai, T., Nakamura, H
  • Journal Title: Dental Materials Journal Volume: 30(1) Pages: 52-57
• [Journal Article] In vitro biocompatibility of dextrin : the addition of a low-concentration of dextrin in the medium promotes the cell activity of L929 mouse fibroblasts (2011)
  • Author(s): Asai, T., Hayashi, T., Kuroki, K., Okano, M., Kiriyama, T., Kawai, T
  • Journal Title: Cell Biology International Volume: 35 Pages: 645-648
• [Journal Article] Fundamental research on the mechanical properties of resin products using selective laser sintering molding (2010)
  • Author(s): Iseda, A., Ishikawa, A., Kawai, T., Sato, Y., Abe, A., Hamajima, S., Asakura, M., Mi zuno, T., Murakami, H., Hattori, M
  • Journal Title: Aichi Gakuin Dent Sci Volume: 23 Pages: 1-8
• [Journal Article] Human acid-insoluble dentin with BMP-2 accelerates bone induction in subcutaneous and intramuscular tissues (2010)
  • Author(s): Murata, M., Kawai, T., Kawakami, T., Akazawa, T., Tazaki, J., Ito, K., Kusano, K., Arisue, M
  • Journal Title: Journal of the Ceramic Society of Japan Volume: 118(6) Pages: 438-441
• [Presentation] Osteoinductive activity of BMP-Metal composite material (2011)
  • Author(s): Ueda, N., Kawai, T., Hayashi, T., Tsuruta, S., Taniyama, M., Hamajima, S., Sato, Y., Kobayashi, S., Ohno, Y., Uematsu, Y
  • Organizer: The international dental materials congress 2011
  • Place of Presentation: seoul
  • Year and Date: 2011-05-29
• [Presentation] Bone-like tissue induced by rhBMPs in vitro has Ossification potential in vitro (2011)
  • Author(s): Hayashi, T., Asai, T., Asakura, M., Sasaki, K., Uematsu, Y., Mieki, A., Kataoka, H., Kawai, T
  • Organizer: The international dental materials congress 2011
  • Place of Presentation: seoul
  • Year and Date: 2011-05-29
• [Presentation] The Basic experiment about the effective of sintered titanium dioxide as a bone filling material (2011)
  • Author(s): Asai, T., Hayashi, T., Kuroki, K., Mieki, A., Kataoka, H., Kawai, T
  • Organizer: The international dental materials congress 2011
  • Place of Presentation: seoul
  • Year and Date: 2011-05-28
• [Presentation] Surface analysis of titanium influenced by plasma glow discharge (2011)
  • Author(s): Muraji, N., Iwata, T., Kawai, T., Ueda, N., Miyazawa, K., Goto, S., Tanaka, Y
  • Organizer: The international dental materials congress 2011
  • Place of Presentation: seoul
  • Year and Date: 2011-05-28
• [Presentation] rhBMPs induce immature muscular tissue to differentiate into bone-like tissue (2010)
  • Author(s): Hayashi, T., Asai, T., Mieki, A., Kataoka, H, Hamajima, S., Sato, Y., Asakura, M., Kawai, T
  • Organizer: 88th General Session & Exhibition of IADR
  • Place of Presentation: Barecelona
  • Year and Date: 20100714-17
• [Presentation] Application of Dextrin as a crude BMP Carrier (2010)
  • Author(s): Asai, T., Hayashi, T., Mieki, A., Kataoka, H., Hamajima, S., Kiriyama, T., Kawai, T
  • Organizer: IADR 88th General Session Exhibition of IADR
  • Place of Presentation: Barecelona
  • Year and Date: 2010-07-15
• [Presentation] Development of Bone Filling Material Made from the Dextrin Complex (2009)
  • Author(s): Asai T., Hayashi T., Hamajima S., Mieki A., Kataoka H., Kawai T
  • Organizer: 87th General Session & Exhibition of IADR
  • Place of Presentation: Miami
  • Year and Date: 2009-04-04
• [Presentation] PVDC Film Decreases the Toxicity of Bonding Agents (2009)
  • Author(s): Hamajima S., Hayashi T., Asai T., Kataoka H., Mieki A., Kawai T
  • Organizer: 87th General Session & Exhibition of IADR
  • Place of Presentation: Miami
  • Year and Date: 2009-04-03
• [Patent(Industrial Property Rights)] 形状記憶樹脂及びそれを用いた歯列矯正器具、並びに形状記憶樹脂の粘弾特性の制御方法 (2011)
  • Inventor(s): 河合達志, 他4名
  • Industrial Property Rights Holder: 河合達志, 他4名
  • Industrial Property Number: 特許、PCT/JP2011/068065JP2011/068065
  • Filing Date: 2011-08-08
• [Patent(Industrial Property Rights)] 形状記憶樹脂及びそれを用いた歯列矯正器具、並びに形状記憶樹脂の粘弾特性の制御方法 (2011)
  • Inventor(s): 河合達志, 他4名
  • Industrial Property Rights Holder: 河合達志, 他4名
  • Industrial Property Number: 特許、特願2011-028328
  • Filing Date: 2011-02-14
• [Patent(Industrial Property Rights)] Bone filling material comprising sintered titanium dioxide and dextrin and method for reconstructing bone defects using the same (2010)
  • Inventor(s): 河合達志, 他1名
  • Industrial Property Rights Holder: 愛知学院大学、松谷化学工業(株)
  • Industrial Property Number: 特許、12879858
  • Filing Date: 2010-09-09
  • Overseas