Strategic research for the identification of novel osteogenic small compounds and their application to bone regeneration

2010 Fiscal Year Final Research Report

• Project/Area Number: 20390509
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: MORI Yoshiyuki The University of Tokyo, 医学部附属病院, 准教授 (70251296)
• Co-Investigator(Kenkyū-buntansha): CHIKAZU Daichi 東京医科大学, 医学部, 教授 (30343122) ; OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623) ; SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390) ; TEI Yuichi 東京大学, 大学院・工学系研究科, 教授 (30345053)
• Project Period (FY): 2008 – 2010
• Keywords: 骨再生療法 / 骨形成性低分子化合物

Research Abstract

This study aims to develop fundamental technologies for small compound-based bone regenerative medicine through the identification of novel osteogenic small compounds, the development of effective drug delivery system, and the assessment of bone regeneration activities of such compounds in bone defect models. Here we identified glabrisoflavone and icariin as osteogenic small compounds. In addition, we established calcium phosphate-based systems for the controlled release of those compounds, and verified their bone regeneration activities in animal models.

Research Products

• [Journal Article] Enhancement of boneformation ex vivo and in vivo by a helioxanthin-derivative. (2010)
  • Author(s): Nakajima K, Komiyama Y, Hojo H, Ohba S, Yano F, Nishikawa N,Ihara S, Aburatani H, Takato T, Chung UI
  • Journal Title: Biochem Biophys Res Commun. 395(4) Pages: 502-508
  • Peer Reviewed
• [Journal Article] Icariin : a potential osteoinductive compound for bone tissueengineering. (2010)
  • Author(s): Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T
  • Journal Title: Tissue Eng Part A. 16(1) Pages: 233-243
  • Peer Reviewed
• [Journal Article] Trehalose inhibits oral dryness by protecting the cell membrane. (2010)
  • Author(s): Mori Y, Yano F, Shimohata N, Suzuki S, Chung UI, Takato T
  • Journal Title: Int J Oral Maxillofac Surg. 39(9) Pages: 916-921
  • Peer Reviewed
• [Journal Article] Tumor-induced osteomalacia associated with a maxillofacial tumor producing fibroblast growth factor 23 : report of a case and review of the literature. (2010)
  • Author(s): Mori Y, Ogasawara T, Motoi T, Shimizu Y, Chikazu D, Tamura K, Fukumoto S, Takato T
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 109(3) Pages: 57-63
  • Peer Reviewed
• [Journal Article] A bone harvesting method involving a surgical template prepared using a three-dimensional model. (2010)
  • Author(s): Saijo H, Kanno Y, Mori Y, Chikazu D, Iino M, Takato T
  • Journal Title: Asian. J. Oral.Maxillofac. Surg. 22 Pages: 20-22
  • Peer Reviewed
• [Journal Article] Unilateral expansion of a narrow mandibular dental arch combined with bimaxillary osteotomies in a patient with hypoglossia. (2009)
  • Author(s): Mori Y, Susami T, Chikazu D, Saijo H, Sakiyama M, Matsuzaki M, Abe M, Wada M, Iino M, Takato T
  • Journal Title: Int J Oral Maxillofac Surg. 38(6) Pages: 689-693
  • Peer Reviewed
• [Journal Article] Development of high-throughput screening system for osteogenicdrugs using a cell-based sensor. (2008)
  • Author(s): Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y,Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI
  • Journal Title: Biochem Biophys Res Commun. 376(2) Pages: 375-379
  • Peer Reviewed
• [Journal Article] Icariininduces osteogenic differentiation in vitro in a BMP- andRunx2-dependent manner. (2008)
  • Author(s): Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T
  • Journal Title: Biochem Biophys Res Commun. 369(2) Pages: 444-448
  • Peer Reviewed
• [Presentation] 口唇口蓋裂患者における二段階上顎骨延長・下顎後方移動術を用いた 外科的矯正治療の治療結果 (2010)
  • Author(s): 須佐美隆史,森良之,大久保和美,長濱浩平,西條英人,高戸毅
  • Organizer: 第28回日本頭蓋顎顔面外科学会学術集会
  • Place of Presentation: 京都大学(吉田キャンパス), 京都
  • Year and Date: 20101028-20101029
• [Presentation] A novel method for designing and fabricating custom-made artificial bones. (2010)
  • Author(s): Kanno Y, Takato T, Saijo H, Igawa K, Seto I, Mori Y, Ohkubo K, Sasaki N, Suzuki S, Chung UI
  • Organizer: Bernd-Spiessl-Symposium 2010
  • Place of Presentation: Basel, Switzerland
  • Year and Date: 2010-06-18
• [Presentation] 進行性骨化性線維異形成症(FOP)患者に対する全身麻酔下での抜歯経験 (2009)
  • Author(s): 森良之,須佐美隆史,西條英人,菅野勇樹,近津大地,末永英之,杉山円,前田祐二郎,斎藤健太郎,飯野光喜,高戸毅
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌コンベンションセンター, 北海道
  • Year and Date: 20091009-20091011
• [Presentation] Cyclooxygenase-2は膜性骨の骨折治癒におけるkey factorである (2009)
  • Author(s): 近津大地,藤川由美子,末永英之,杉山円,古賀陽子,阿部雅修,西條英人,森良之,飯野光喜,高戸毅
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌コンベンションセンター, 北海道
  • Year and Date: 20091009-20091011
• [Presentation] Hemifacial microsomiaに対する下顎骨延長術における工夫 (2008)
  • Author(s): 森良之,須佐美隆史,西條英人,大久保和美,近津大地,松崎雅子,仲宗根愛子,飯野光喜,高戸毅
  • Organizer: 第18回日本顎変形症学会総会
  • Place of Presentation: 名古屋国際会議場, 愛知県
  • Year and Date: 20080617-20080618
• [Presentation] 骨移植および歯槽骨延長による歯槽骨造成法 (2008)
  • Author(s): 森良之
  • Organizer: 第29回日本口腔外科学会 教育研修会
  • Place of Presentation: 富士ソフトアキバプラザ, 東京
  • Year and Date: 20080216-20080217
• [Book] 形成外科診療プラクティス 顔面骨骨折の治療の実際(平野明喜/一瀬正治/保坂善昭編集)(3.下顎関節突起骨折における保存的治療) (2010)
  • Author(s): 森良之・高戸毅,須佐美隆史
  • Total Pages: 324(286-289)
  • Publisher: 文光堂
• [Book] 医師・歯科医師のための口腔診療必携;困ったときのマニュアル・ヒント集202(高戸毅監修)(5.口腔粘膜に白斑のある患者が来院したら?) (2010)
  • Author(s): 森良之
  • Total Pages: 263(9)
  • Publisher: 金原出版
• [Remarks] 東京大学医学部附属病院顎口腔外科・歯科矯正歯科ホームページ
  • URL: http://plaza.umin.ac.jp/~oralsurg/