2011 Fiscal Year Final Research Report
The origin and genome diversity of retroviruses causing neurological disorders
| Project/Area Number |
20405039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
OCHIAI Kenji 北海道大学, 大学院・獣医学研究科, 准教授 (80214162)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Kazuhiko 北海道大学, 大学院・獣医学研究科, 教授 (90250498)
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| Project Period (FY) |
2008 – 2011
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| Keywords | グリオーマ / 鶏 / 中枢神経系腫瘍 / 分子系統進化 / トリ白血病ウイルス / レトロウイルス |
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| Research Abstract |
Fowl glioma is caused by fowl glioma-inducing virus (FGV), belonging to subgroup A of avian leucosis virus (ALV-A). To clarify how and where FGV emerged, the prevalence of FGV in European, Asian and Japanese native chickens were examined and the viral genome of the isolates were analyzed. The results suggest that FGV is likely to have appeared in Japanese fowls in Japan without a relationship to the past fowl glioma found in Western countries, and that FGV and FGV vatriants still spread in Japanese fowls, showing genome diversity mainly based on the recombination between these strains and avian endogenous/exogenous viruses.
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