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2010 Fiscal Year Self-evaluation Report

Problems and the solution in the final stage of the global program to eliminate lymphatic filariasis

Research Project

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Project/Area Number 20406010
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionAichi Medical University

Principal Investigator

KIMURA Eisaku  Aichi Medical University, 医学部, 教授 (70153187)

Project Period (FY) 2008 – 2011
Keywordsフィラリア症 / 免疫診断 / 尿 / IgG4 / 象皮病
Research Abstract

WHO主導の世界フィラリア症(F症)征圧計画は、集団治療(MDA)の実施により大きな成果をあげ、今後の課題は、F症根絶の確認と再燃の監視に移った。それには感度の高い診断法が必須で、我々は、血液の代わりに尿を用いる尿ELISAの有用性と意義を強調してきた。本研究では、MDA後の低流行地で尿診断の価値を再確認すると共に以下を行う。
(1)F症の根絶確認,再燃の早期発見のための判定基準を確立する。
(2)見逃されている流行地を発見する。
(3)象皮病患者の治療、および遺伝学的背景に関する研究を行う。
(4)目視による尿診断法を開発し応用する。
(5)LAMP法の導入によるフィラリア媒介蚊の感染率調査を実施し、根絶の指標としての媒介蚊の意義を明らかにする。

  • Research Products

    (12 results)

All 2011 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Book (1 results)

  • [Journal Article] The Global Programme to Eliminate Lymphatic Filariasis : History and achievements with special reference to annual single-dose treatment with di-ethylcarbamazine in Samoa and Fiji.2011

    • Author(s)
      Kimura E.
    • Journal Title

      Trop Med Health 39

      Pages: 17-30

    • Peer Reviewed
  • [Journal Article] Study on association between genetic polymorphisms of haem oxygenase-1, tumour necrosis factor, cadmium exposure and malaria pathogenicity and severity.2010

    • Author(s)
      Kuesap J, Hirayama K, Kikuchi M, Ruangweerayut R, Na-Bangchang K.
    • Journal Title

      Malaria J 9

      Pages: 260

    • Peer Reviewed
  • [Journal Article] Enzyme-linked immunosorbent assay to detect urinary antibody against recombinant rKRP42 antigen made from Leishmania donovani for the diagnosis of visceral leishmaniasis.2008

    • Author(s)
      Islam MZ, Itoh M, Takagi H, Kimura E, 他5人
    • Journal Title

      Am J Trop Med Hyg 79

      Pages: 599-604

    • Peer Reviewed
  • [Journal Article] Distribution of filarial elephantiasis and hydrocele in Matara district, Sri Lanka, as reported by local leaders, and an immunological survey in areas with relatively high clinical rates.2008

    • Author(s)
      Weerasooriya MV, Itoh M, Kimura E, 他4人
    • Journal Title

      Parasitol Int 57

      Pages: 390-395

    • Peer Reviewed
  • [Journal Article] Presence and gradual dis-appearance of filaria-specific urinary IgG4 in babies born to antibody-positive mothers : A 2-year follow-up study.2008

    • Author(s)
      Weerasooriya MV, Itoh M, Kimura E, 他3人
    • Journal Title

      Parasitol Int 57

      Pages: 386-389

    • Peer Reviewed
  • [Presentation] Evaluation of urine-based IgG4 ELISA for detecting lymphatic filarial infection and the development of a visual diagnostic method with urine samples.2011

    • Author(s)
      Kimura E, et al.
    • Organizer
      45th Annual Japan-US Joint Conference on Parasitic Diseases.
    • Place of Presentation
      NIH, Tokyo.
    • Year and Date
      20110110-20110111
  • [Presentation] Diagnosis of a mosquito-borne disease : Use of urine samples for detecting filarial infection in a monitoring program after successful mass drug administration.2010

    • Author(s)
      Kimura E, et al.
    • Organizer
      The 2nd Int Conference on Climate Change and Neglected Tropical Diseases.
    • Place of Presentation
      Dhaka, Bangladesh.
    • Year and Date
      20100929-20100930
  • [Presentation] Evaluation of two monitoring schemes after one year of community home-based care (CHBC) programme of morbidity control in lymphatic filariasis in three suburbs of Matara, Sri Lanka.2010

    • Author(s)
      Yahathugoda TC, et al.
    • Organizer
      XIIth Int Congress of Parasitol.
    • Place of Presentation
      Melbourne, Australia.
    • Year and Date
      20100815-20100820
  • [Presentation] Linkage analysis of elephantiasis by affected sib-pairs in Sri Lanka.2009

    • Author(s)
      Weerasooriya MV, et al.
    • Organizer
      68th Annual Academic Sessions, Galle Medical Association.
    • Place of Presentation
      Galle, Sri Lanka.
    • Year and Date
      20090910-20090912
  • [Presentation] Immunodiagnosis of lymphatic filariasis using urine samples and its field application in Sri Lanka and China.2008

    • Author(s)
      Kimura E.
    • Organizer
      Joint Int Trop Med Meeting.
    • Place of Presentation
      Bangkok, Thailand.
    • Year and Date
      20081013-20081014
  • [Presentation] Urine-based immunodiagnosis with children to monitor mass drug administrations, confirm elimination and detect resurgence of filarial infection.2008

    • Author(s)
      Kimura E.
    • Organizer
      17th Int Congress for Trop Med and Malaria.
    • Place of Presentation
      Jeju, Korea.
    • Year and Date
      20080929-20081003
  • [Book] 新領域別症候群シリーズ,No.8呼吸器症候群(第2版)イヌ糸状虫症2008

    • Author(s)
      木村英作
    • Total Pages
      3
    • Publisher
      日本臨床社

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Published: 2012-02-13   Modified: 2016-04-21  

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