2011 Fiscal Year Final Research Report
Characteristics of pulmonary circulation in high-altitude active animals-Biomolecular study focusing on the central role of Rho-kinase
| Project/Area Number |
20406021
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUKAWA Shigeru 福井大学, ライフサイエンス支援センター, 准教授 (00092809)
SAKAI Akio 松本大学, 人間健康学部, 教授 (70020758)
KOIZUMI Tomonori 信州大学, 医学部附属病院, 准教授 (20273097)
TOGA Hirohisa 金沢医科大学, 医学部, 教授 (90142554)
AMESHIMA Shingo 福井大学, 医学部附属病院, 講師 (60262614)
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| Research Collaborator |
ALMAZ Aldashev キルギス国立分子生物医学センター, センター長
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| Project Period (FY) |
2008 – 2011
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| Keywords | 高地適応動物 / ヤク / ウシ / high-altitude pulmonary hypertension(HAPH) / Rhoキナーゼ / エンドセリン / 肺高血圧症 / 右心カテーテル法 |
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| Research Abstract |
Despite in the hypoxic air circumstance, yak, a high-altitude living animal, has never developed high-altitude pulmonary hypertension(HAPH). The reason behind it is that a Rho-kinase, an essential enzyme of maintaining of vascular tone is not activated in the pulmonary vessels. There is no remodeling of pulmonary arterial wall in yak. On the contrary, a bull or Kyrgyzstan people who are living at high-altitude and having HAPH have augmented activity of Rho-kinase.
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