Surveillance of current incidence and infrastructure development of international collaboration for childhood liver cancers by Japanese study group for pediatric liver tumor

2010 Fiscal Year Final Research Report

• Project/Area Number: 20406028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Pediatric surgery
• Research Institution: Hiroshima University
• Principal Investigator: HIYAMA Eiso Hiroshima University, 自然科学研究支援開発センター, 教授 (00218744)
• Co-Investigator(Kenkyū-buntansha): TAJIRI Tatsuro 九州大学, 医学研究科, 准教授 (80304806) ; OUE Takaharu 大阪大学, 医学研究科, 助教 (50314315) ; KAMIMATSUSE Arata 広島大学, 病院, 病院助教 (90569881) ; HISHIKI Tomoro 千葉大学, 大学院・医学研究院, 講師 (00375776) ; IDA Koumei 東京大学, 医学部・附属病院, 准教授 (60313128) ; YAMAOKA Hiroaki 広島大学, 病院, 講師 (90311810) ; NISHIMURA Shinichiro 広島大学, 医歯薬学総合研究科, 准教授 (00228222)
• Co-Investigator(Renkei-kenkyūsha): KONDO Satoshi 名古屋市立大学, 医学研究科, 講師 (50234935) ; WATANABE Kenichiro 京都大学, 医学研究科, 講師 (20324634) ; YANO Michihiro 秋田大学, 医学部, 助教 (40321997)
• Project Period (FY): 2008 – 2010
• Keywords: 癌 / 医療・福祉 / 薬剤反応性 / トランスレーショナルリサーチ / 外科

Research Abstract

We conducted overseas research, mainly in Europe (SIOPEL) and North America(COG), on cases of hepatoblastoma, which account for over 80% of all pediatric liver tumors.. In Japan, the rate of incidence was higher than in these countries, but the incidence of pathologically small undifferentiated tumors was lower.. According to the outcome of the patients, we stratified the hepatoblastoma patients into three risk groups : standard, intermediate, and high risks and proposed new treatment protocols for each group. We also built a new pathological classification scheme and registration database, to pave the way for international collaboration in infrastructure development for clinical trials.

Research Products

• [Journal Article] Outcome of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol-2 : report from the JPLT. (2011)
  • Author(s): Hishiki T, Matsunaga T, Sasaski F, Yano M, Ida K, Horie H, Kondo S, Watanabe K, Oue T, Tajiri T, Kamimatsuse A, Ohnuma N, Hiyama E
  • Journal Title: Pediatr Surg Int. 27(1) Pages: 1-8
  • Peer Reviewed
• [Journal Article] Telomere Maintenance as Therapeutic Target in Embryonal Tumours. (2010)
  • Author(s): Shalaby T, Hiyama E, Grotzer MA.
  • Journal Title: Anticancer Agents Med Chem. 10(3) Pages: 196-212
  • Peer Reviewed
• [Journal Article] Increased expression of the hedgehog signaling pathway in pediatric solid malignancies. (2010)
  • Author(s): Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.
  • Journal Title: Journal of Pediatric Surgery. 45(2) Pages: 387-392
  • Peer Reviewed
• [Journal Article] Forskolin, a Hedgehog signal inhibitor, inhibits cell proliferation and induces apoptosis in pediatric tumor cell lines. (2010)
  • Author(s): Yamanaka H, Oue T, Uehara S, Fukuzawa M.
  • Journal Title: Molecular Medicine Reports. 3(1) Pages: 133-139
  • Peer Reviewed
• [Journal Article] Reevaluation of trkA expression as a biological marker of neuroblastoma by high sensitivity expression analysis-a study of 106 primary neuroblastomas treated in a single institute. (2010)
  • Author(s): Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H.
  • Journal Title: J Pediatr Surg. 45(12) Pages: 2293-2298
  • Peer Reviewed
• [Journal Article] 肝芽腫の標準治療 (2010)
  • Author(s): 山岡裕明, 亀井尚美, 檜山英三
  • Journal Title: 小児がん 47 Pages: 25-30
• [Journal Article] 状態不良により化学療法の減量を行ったPRETEXT IV肝芽腫の1切除例 (2010)
  • Author(s): 原秀一郎, 楠木重範, 山中宏晃, 上野豪久, 佐藤恵実子, 橋井佳子, 太田秀明, 大植孝治, 福澤正洋
  • Journal Title: 小児がん 4(3) Pages: 466-470
  • Peer Reviewed
• [Journal Article] 小児がんの現状と今後 (2010)
  • Author(s): 檜山英三
  • Journal Title: 日本小児放射線学会雑誌 26(1) Pages: 11-16
• [Journal Article] Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR : recommendations by the International Neuroblastoma Risk Group Task Force. (2009)
  • Author(s): Beiske K, Burchill SA, Cheung IY, Hiyama E, Seeger RC, Cohn SL, Pearson AD, Matthay KK.
  • Journal Title: Br J Cancer. 100(10) Pages: 1627-1637
  • Peer Reviewed
• [Journal Article] Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array. (2009)
  • Author(s): Kamimatsuse A, Matsuura K, Moriya S, Fukuba I, Yamaoka H, Fukuda E, Kamei N, Hiyama K, Sueda T, Hiyama E
  • Journal Title: Pediatr Blood Cancer. 52(7) Pages: 777-783
  • Peer Reviewed
• [Journal Article] P1k1 regulates liver tumor cell death by phosphorylation of TAp63. (2009)
  • Author(s): Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A, Kamijo T.
  • Journal Title: Oncogene. 28(41) Pages: 3631-3641
  • Peer Reviewed
• [Journal Article] A preoperative evaluation for neo-infantile liver tumors using a three-dimensional reconstruction of multidetector row CT. (2009)
  • Author(s): Kinoshita Y, Souzaki R, Tajiri T, Ieiri S, Taguchi T.
  • Journal Title: Oncol Rep. 21(4) Pages: 881-886
  • Peer Reviewed
• [Journal Article] 小児の固形腫瘍-がん診療update- (2009)
  • Author(s): 檜山英三
  • Journal Title: 日本医師会雑誌 138(特別号1) Pages: 286-288
• [Journal Article] The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients. (2008)
  • Author(s): Honda S, Haruta M, Sugawara W, Sasaki F, Ohira M, Matsunaga T, Yamaoka H, Horie H, Ohnuma N, Nakagawara A, Hiyama E, Todo S, Kaneko Y.
  • Journal Title: Int J Cancer. 123(5) Pages: 1117-1125
  • Peer Reviewed
• [Journal Article] Effectiveness of screening for neuroblastoma at 6 months of age : a retrospective population-based cohort study. (2008)
  • Author(s): Hiyama E, Iehara T, Sugimoto T, Fukuzawa M, Hayashi Y, Sasaki F, Sugiyama M, Kondo S, Yoneda A, Yamaoka H, Tajiri T, Akazawa K, Ohtaki M.
  • Journal Title: Lancet. 371(9619) Pages: 1173-1180
  • Peer Reviewed
• [Journal Article] Diagnostic value of lectin reactive alpha-fetoprotein for neo-infantile hepatic tumors and malignant germ cell tumors-Preliminary Study-. (2008)
  • Author(s): Kinoshita Y, Tajiri T, Souzaki R, Tatsuta K, Higashi M, Izaki T, Takahashi Y, Taguchi T
  • Journal Title: J Pediatr Hematol/Oncol. 30(6) Pages: 447-450
  • Peer Reviewed
• [Journal Article] 日本における遺伝子診療・研究の現状 (2008)
  • Author(s): 檜山桂子, 谷本圭司, 檜山英三
  • Journal Title: 腫瘍内科 2(5) Pages: 433-439
• [Journal Article] タンデムMSによる疾患関連分子マーカーの探索 (2008)
  • Author(s): 津山尚広, 水野初, 原田隆範, 西垣俊太, 升島努, 前田昌子, 檜山英三
  • Journal Title: 臨床化学 37(4) Pages: 410-417
• [Journal Article] JPLTのプロトコールに従って術前化学療法を施行した新生児肝芽腫の1例 (2008)
  • Author(s): 大植孝治, 山中宏晃, 谷岳人, 上原秀一郎, 米田光宏, 楠木重範, 時政定雄, 橋井佳子, 太田秀明, 福澤正洋
  • Journal Title: 小児がん 45(3) Pages: 307-311
• [Presentation] 小児肝腫瘍に対する治療の現状と将来 (2011)
  • Author(s): 檜山英三
  • Organizer: 第40回九州地区小児固形悪性腫瘍研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-02-19
• [Presentation] JPLT2における高リスク群肝芽腫症例の検討 (2010)
  • Author(s): 上松瀬新, 菱木知郎, 田尻達郎, 渡邊健一郎, 矢野道広, 堀江弘, 井田孔明, 近藤知史, 大植孝治, 佐々木文章, 檜山英三
  • Organizer: 第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-12-17
• [Presentation] 難治性肝芽腫の治療～拡大肝切除・転移巣切除・IVR (2010)
  • Author(s): 菱木知郎, 佐々木文章, 矢野道広, 井田孔明, 堀江弘, 近藤知史, 渡邊健一郎, 大植孝治, 田尻達郎, 檜山英三
  • Organizer: 第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-12-17
• [Presentation] 小児肝癌の国際的標準治療法の確立に関する研究 (2010)
  • Author(s): 檜山英三, 上松瀬新, 菱木知郎, 田尻達郎, 渡邊健一郎, 矢野道広, 井田孔明, 近藤知史, 大植孝治, 西村真一郎, 堀江弘
  • Organizer: 第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-12-17
• [Presentation] 肝芽腫におけるβカテニンの転写調節に関与するBRG1およびTERT発言に関する検討 (2010)
  • Author(s): 上田祐華, 上松瀬新, 亀井尚美, 檜山英三
  • Organizer: 第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-12-17
• [Presentation] 血管内進展きたしαフェトプロテイン高値のまま生体肝移植を実施した肝芽腫の2例 (2010)
  • Author(s): 上野豪久, 野村元成, 正畠和典, 吉田寿雄, 長谷川泰浩, 井原欣幸, 高間勇一, 神山雅史、上原秀一郎, 大植孝治, 橋井佳子, 太田秀明, 近藤宏樹, 長谷川利路, 福澤正洋
  • Organizer: 第26回日本小児がん学会学術集会
  • Place of Presentation: 大阪.
  • Year and Date: 2010-12-17
• [Presentation] Outcome of Hepatoblastoma Treated with the JPLT-2 Protocol from the Experience of JPLT (Study Group for Pediatric Liver Tumor) Study. (2010)
  • Author(s): Hiyama E, Kamimatsuse A, Kamei N, Watanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Sasaki F, Horie H, Ounuma N.
  • Organizer: SIOP2010.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2010-10-21
• [Presentation] 小児がん治療における小児外科の役割小児肝芽腫に対するJPLT-2プロトコールの治療成績 (2010)
  • Author(s): 上松瀬新, 菱木知郎, 亀井尚美, 田尻達郎, 渡邊健一郎, 矢野道広, 堀江弘, 井田孔明, 近藤知史, 大植孝治, 佐々木文章, 大沼直躬, 檜山英三
  • Organizer: 第47回日本小児外科学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-17
• [Presentation] Japanese Study for pediatric Liver Tumor. Cisplatin plus pirarubicin chemotherapy and combination ifomide, etoposide, pirarubicin, and carboplatin chemotherapy for hepatoblastoma. (2010)
  • Author(s): Hiyama E, Kamimatsuse A, kamei N, Wartanabe K, Hishiki T, Tajiri T, Ida K, Yano M, Kondo S, Sasaki F
  • Organizer: ASCO 10^<th> Annual Meeting.
  • Place of Presentation: Chicago
  • Year and Date: 2010-06-04
• [Presentation] 心不全により全身状態不良であったPRETEXT IV 肝芽腫の1新生児例 (2009)
  • Author(s): 上原秀一郎, 大植孝治, 山中宏晃, 上野豪久, 楠木重範, 橋井佳子, 太田秀明, 福澤正洋
  • Organizer: 第25回小児がん学会
  • Place of Presentation: 浦安
  • Year and Date: 2009-11-27
• [Presentation] Increased expression of the hedgehog signaling pathway in pediatric solid malignancies. (2009)
  • Author(s): Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.
  • Organizer: 56^<th> British Assocation of Paediatric Surgeons
  • Place of Presentation: Graz, Austlia.
  • Year and Date: 2009-06-18
• [Presentation] JPLT studies. (2009)
  • Author(s): 檜山英三
  • Organizer: SIOPEL Meeting 2009.
  • Place of Presentation: Munich, Germany
  • Year and Date: 2009-03-03
• [Presentation] 小児悪性固形腫瘍の最近のトピックス (2009)
  • Author(s): 檜山英三
  • Organizer: 第37回青森小児血液・腫瘍研究会
  • Place of Presentation: 青森市
  • Year and Date: 2009-02-28
• [Presentation] 2008年に経験した肝芽腫PRETEXT IIIの4例 (2009)
  • Author(s): 宗崎良太、田尻達郎、田中桜、木下義晶、古賀友紀、住江愛子、松崎彰信、原寿郎、田口智章
  • Organizer: 第38回九州地区小児固形悪性腫瘍研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-02-28
• [Presentation] 全身状態不良のためJPLTのプロトコールが施行不能であったPRETEXT4肝芽腫の1例 (2009)
  • Author(s): 大植孝治, 上原秀一郎, 山中宏晃, 福澤正洋, 楠木重範, 太田秀明
  • Organizer: JPLT研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] JPLT08登録PRETEXT IIIの4例 (2009)
  • Author(s): 宗崎良太、田尻達郎、田中桜、木下義晶、古賀友紀、住江愛子、松崎彰信、原寿郎、田口智章
  • Organizer: JPLT研究会2009
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] 守る会助成課題小児肝癌の国際的標準治療法の確立に関する研究:治療成績向上と晩期障害軽減を目指して (2008)
  • Author(s): 山岡裕明, 檜山英三, 田尻達郎, 渡辺健一郎, 矢野道広, 菱木知郎, 堀江弘, 井田孔明, 近藤知史, 西村真一郎, 大植孝治, 佐々木文章
  • Organizer: 第24回日本小児がん学会
  • Place of Presentation: 千葉市
  • Year and Date: 2008-11-14
• [Presentation] Duplication of paternal IGF2, loss of maternal IGF2 imprinting or P3 hypomethylation occurs in most hepatoblastomas. (2008)
  • Author(s): 金子安比古, 本多昌平, et al.
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-28
• [Presentation] 小児がん診療の最前線 (2008)
  • Author(s): 檜山英三
  • Organizer: 呉共済病院オープンカンファレンス
  • Place of Presentation: 広島県呉市
  • Year and Date: 2008-10-16
• [Presentation] Effectiveness and complications of treatment for childfood liver tumors-from the experience of JPLT(Japanese Study Group for Pediatric Liver Tumor)study. (2008)
  • Author(s): Hiyama E, Yamaoka H, Nishimura S, Hishiki T, Hiyama K, Sasaki F, Horie H, Ohnuma N.
  • Organizer: EHRLICH II-2nd World Conference on Magic Bullets Celebrating the 100th Anniversary of the Nobel Prize Award of Paul Ehrlich.
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2008-10-03
• [Presentation] 成人固形がん:テロメラーゼ陽性"幹細胞"からの発がん機構 (2008)
  • Author(s): 檜山桂子, Arfin M, 麓祥一, 谷本圭司, 檜山英三, 西山正彦
  • Organizer: 第26回日本ヒト細胞学会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2008-08-30
• [Presentation] Increased expression of multi-drug resist assocoated genes after chemo therapy in pesiatric solid malignancies. (2008)
  • Author(s): Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M.
  • Organizer: 55^<th> British Assocation of Paediatric Surgeons, Salamanca.
  • Place of Presentation: Spain.
  • Year and Date: 2008-07-02
• [Presentation] Beckwith-Wiedemann症候群に発症した肝芽腫の1例 (2008)
  • Author(s): 山岡裕明, 檜山英三, 鬼武美幸, 小野厚, 西村真一郎, 小林正夫, 末田泰二郎
  • Organizer: 第48回中国四国小児がん研究会
  • Place of Presentation: 香川県
  • Year and Date: 2008-04-07
• [Book] Telomeres and Telomerase in Cancer. (2009)
  • Author(s): Hiyama E, Hiyama K Shay JW.
  • Total Pages: 3-21
  • Publisher: Humana Press.
• [Book] Regulatory Networks in Stem Cell. (2009)
  • Author(s): Hiyama E, Hiyama K.
  • Total Pages: 123-133
  • Publisher: Humana Press.
• [Book] Clinical application of molecular diagnosis in cancer, radiation effect, and human diseases. (2009)
  • Author(s): Hiyama E, Hiyama K.
  • Total Pages: 220
  • Publisher: Humana Press.
• [Remarks] ホームページ等
  • URL: http://home.hiroshima-u.ac.jp/eiso/