2012 Fiscal Year Final Research Report
A Molecular-epidemiological study of oral and maxillofacial disease among the residents living in Semipalatinsk nuclear test site in Kazakhstan
| Project/Area Number |
20406030
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKAMOTO Tetsuji 広島大学, 大学院・医歯薬保健学研究院, 教授 (00169153)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Yukio 広島大学, 大学院・医歯薬保健学研究院, 助教 (20335665)
FUKUI Yasuto 広島大学, 大学院・医歯薬保健学研究院, 助教 (90363085)
HOSHI Masaharu 広島大学, 原爆放射線医科学研究所, 名誉教授 (50099090)
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| Project Period (FY) |
2008 – 2012
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| Keywords | セミパラチンスク核実験場 / 低線量放射線被ばく / 先天異常 / 分子疫学 / 遺伝子多型 / 口腔疾患罹患率 / 唇顎口蓋裂発症率 / 顎口腔顔面疾患 |
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| Research Abstract |
From1949 to 1989, 30 surface, 88 atmospheric and 340 underground nuclear and thermonuclear explosions of nuclear weapons were carried out by former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) in Kazakhstan that resulted in high local fallout affecting the residents in the villages adjacent to the SNTS. The radiation effect on predisposition of oral and maxillofacial disorders among the exposed people from the SNTS areas remains unknown. The purpose of this study is to investigate a possible relationship between long-term radiation exposure by nuclear testing and predisposition of Oral maxillofacial anomalies such as Cleft lip & Palate (CLP) and oral diseases such as periodontitis. In conclusion, this study strongly suggests that the inhabitants in exposed villages adjacent to SNTS might be considered a population at risk for high prevalence oforal & maxillofacial lesions. It is possible that this heightened risk resulted from long-term radiation exposure.
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Research Products
(41 results)
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[Journal Article] ESR dosimetry study on population of settlements nearby Ust-Kamenogorsk city, Kazakhstan2009
Author(s)
Zhumadilov K, Ivannikov A, Zharlyganova D, Zhumadilov Z, Stepanenko V, Apsalikov K, Ali MR, Zhumadilova A, Toyoda S, Endo S, Tanaka K, Okamoto T, Hoshi M
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Journal Title
Radiat Environ Biophys.
Volume: 48(4)
Pages: 419-25
Peer Reviewed
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