2010 Fiscal Year Final Research Report
Hemodynamics model incorporating baroreflex model
| Project/Area Number |
20500270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyoto University |
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Principal Investigator |
AMANO Akira Kyoto University, 生命科学部, 教授 (60252491)
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| Project Period (FY) |
2008 – 2010
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| Keywords | コンピュータシミュレーション / 循環動態シミュレーション / 生体シミュレーション / 心筋細胞モデル / 圧受容体反射 / 血圧維持 |
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| Research Abstract |
In this research, we developed a comprehensive hemodynamics model which can evaluate the energy metabolism under various conditions. The model is constructed by introducing the beta stimulation system which controls contractility of myocardium. The model can be used as a basic model for evaluating treatments for heart failure which is caused by the efficiency of mechanical pump function of heart by diseases such as myocardial infarction. The model was able to reproduce temporal change of blood pressure under various conditions such as head up tilt test.
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