Subthalamic nucleus stimulation for Parkinson disease : improvement in outcome and assessment of medical economic effect

2010 Fiscal Year Final Research Report

• Project/Area Number: 20500297
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Fukuoka University
• Principal Investigator: BABA Yasuhiko Fukuoka University, 医学部, 講師 (50352258)
• Co-Investigator(Kenkyū-buntansha): YAMADA Tatsuo 福岡大学, 医学部, 教授 (50142211) ; FUKUSHIMA Takeo 福岡大学, 医学部, 教授 (10078735)
• Project Period (FY): 2008 – 2010
• Keywords: 臨床神経科学

Research Abstract

The present study evaluated the factor associated with improvement of outcome and the medical economic effect in deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson disease. The results suggested that the preoperative L-dopa response for motor symptoms contributes the postoperative efficacy with STN-DBS. Additionally, excessive reduction of dopaminergic agents after STN-DBS was a factor related to the emergence of neuropsychiatric symptoms. With STN-DBS therapy, the drug cost of dopaminergic agents was reduced by 86% per year after surgery.

Research Products

• [Journal Article] Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease : A case-control study in Japan (2011)
  • Author(s): Miyake Y., Tanaka K., Fukushima W., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-Parkinsonism Relat Disord. 17 Pages: 112-6
  • Peer Reviewed
• [Journal Article] テーラーメイド治療のための治療薬の選択と使用法ガイドラインパーキンソン病 (2010)
  • Author(s): 馬場康彦,山田達夫
  • Journal Title: Medical Practice 27 Pages: 180-186
• [Journal Article] ふるえのメカニズム (2010)
  • Author(s): 馬場康彦
  • Journal Title: BRAIN NURSING 26 Pages: 30-32
• [Journal Article] しびれや麻痺のメカニズム (2010)
  • Author(s): 馬場康彦
  • Journal Title: BRAIN NURSING 26 Pages: 25-29
• [Journal Article] Alcohol drinking and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Fukushima W., Miyake Y., Tanaka. K., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-BMC Neurol. 10 Pages: 111
  • Peer Reviewed
• [Journal Article] GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population (2010)
  • Author(s): Kiyohara C., Miyake Y., Koyanagi M., Fujimoto T., Shirasawa S., Tanaka K., Fukushima W., Sasaki S., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-Parkinsonism Relat Disord. 16 Pages: 447-52
  • Peer Reviewed
• [Journal Article] Dietary glycemic index is inversely associated with the risk of Parkinson's disease: a case-control study in Japan (2010)
  • Author(s): Murakami K., Miyake Y., Sasaki S,, Tanaka K., Fukushima W., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-J Neurol Sci. 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Dietary fat intake and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Miyake Y., Sasaki S., Tanaka K., Fukushima W., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-J Neurol Sci. 288 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Active and passive smoking and risk of Parkinson's disease (2010)
  • Author(s): Tanaka K., Miyake Y., Fukushima W., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's disease Study Group-Acta Neurol Scand. 122 Pages: 377-382
  • Peer Reviewed
• [Journal Article] Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease : a case-control study in Japan (2010)
  • Author(s): Murakami K., Miyake Y., Sasaki S., Tanaka K., Fukushima W., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-Br J Nutr. 104 Pages: 757-764
  • Peer Reviewed
• [Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan (2010)
  • Author(s): Miyake Y., Tanaka K., Fukushima W., Sasaki S., Kiyohara C., Tsuboi Y., Yamada T., Oeda T., Miki T., Kawamura N., Sakae N., Fukuyama H., Hirota Y., Nagai M.
  • Journal Title: Fukuoka Kinki Parkinson's Disease Study Group-J Neurol Sci. 293 Pages: 82-86
  • Peer Reviewed
• [Journal Article] Atheroscler Thromb. (2009)
  • Author(s): Furuyama S., Uehara Y., Zhang B., Baba Y., Abe S., Iwamoto T., Miura S., Saku K.
  • Journal Title: Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men 16 Pages: 194-200
  • Peer Reviewed
• [Journal Article] Restless legs syndromeを伴うパーキンソン病:視床下核刺激術とプラミペキソールの効果 (2009)
  • Author(s): 馬場康彦、樋口正晃、山田達夫
  • Journal Title: Frontiers in Parkinson Disease 2 Pages: 50-51
• [Journal Article] テーラーメイド治療を目指した治療薬の選択と使用法ガイドラインUpdate.パーキンソン病 (2008)
  • Author(s): 馬場康彦、山田達夫
  • Journal Title: Medical Practice 25 Pages: 1619-1626
• [Journal Article] 脳深部刺激療法;術後薬物治療の最適化 (2008)
  • Author(s): 馬場康彦、樋口正晃、山田達夫
  • Journal Title: Pharma Medica Pages: 2646-51
• [Journal Article] ATP-binding cassette transporter G4 is highly expressed in microglia in Alzheimer's brain (2008)
  • Author(s): Uehara Y., Yamada T., Baba Y., Miura S., Abe S., Kitajima K., Higuchi MA., Iwamoto T., Saku K.
  • Journal Title: Brain Res. 1217 Pages: 239-246
  • Peer Reviewed
• [Journal Article] Eur Effect of chronic kidney disease on excessive daytime sleepiness in Parkinson disease
  • Author(s): Baba Y., Higuchi M., Fukuyama K., Abe H., Uehara U., Inoue T., Yamada T.
  • Journal Title: J Neurol (in press)
  • Peer Reviewed
• [Presentation] DBSの適応の判断に苦慮した一例 (2010)
  • Author(s): 馬場康彦
  • Organizer: 第51回日本神経学会総会イブニングセミナー9
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-22
• [Presentation] DBSのインフォームドコンセントについて (2010)
  • Author(s): 馬場康彦
  • Organizer: 第51回日本神経学会総会ランチョンセミナー26
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-21
• [Presentation] STN-DBS後に出現するapathy:術前予測因子の検討 (2010)
  • Author(s): 樋口正晃、馬場康彦、他
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-05-21
• [Presentation] The effect of subthalamic nucleus stimulation on nonmotor symptoms in Parkinson's disease. (2009)
  • Author(s): Higuchi M, Baba Y, et al.
  • Organizer: WFN XVIII World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 2009-12-15
• [Presentation] Anticholinergic therapy for management of axial symptoms in Parkinson's disease with deep brain stimulation of the subthalamic nucleus. (2009)
  • Author(s): Baba Y, Higuchi M, et al.
  • Organizer: XVIII WFN World Congress on Parkinson's Disease and Related Disorders
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 2009-12-15
• [Presentation] パーキンソン病に対する深部脳刺激術;ドパミン調節異常症候群に対する影響 (2009)
  • Author(s): 樋口正晃、馬場康彦、他
  • Organizer: 第11回福岡神経内科疾患研究会
  • Place of Presentation: ANAクラウンプラザホテル福岡
  • Year and Date: 2009-04-24
• [Presentation] パーキンソン病とrestless legs syndromeに対する視床下核刺激術 (2008)
  • Author(s): 馬場康彦,他
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] パーキンソン病のNon-motor Symptoms : STN-DBS前後の変化について (2008)
  • Author(s): 馬場康彦,他
  • Organizer: 第10回福岡神経内科疾患研究会
  • Place of Presentation: ホテル日航福岡
  • Year and Date: 2008-04-18