2010 Fiscal Year Final Research Report
Analysis of neurite outgrowth and growth cone guidance by using FRET imaging
| Project/Area Number |
20500336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKESHI Nakamura Kyoto University, 生命科学研究所, 教授 (60362604)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞内情報伝達 |
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| Research Abstract |
(1) cAMP plays a pivotal role in neurite growth and guidance, but its downstream pathways leading to the regulation of Rho GTPases, centrally implicated in neuronal morphogenesis, remain elusive. We have shown that phosphorylation of STEF by PKA is critical for Rac1 activation and neurite outgrowth in dbcAMP-treated PC12D cells. (2) We have shown that Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase.
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Research Products
(21 results)
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[Journal Article] mNUDC is required for plus-end directed transport of cytoplasmic dynein and dynactins by kinesin-1.2010
Author(s)
Yamada M, Yoshida Y, Mori D, Takitou T, Nakamura T, Atsuko H, Iwane AH, Yanagida T, Yu-Lee L, Wynshaw-Boris A, Hirotsune S
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Journal Title
EMBO J. 29
Pages: 517-531
Peer Reviewed
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[Journal Article] A unique role of Lis1 for plus-end tracking of cytoplasmic dynein using microtubules as a freighter.2008
Author(s)
Yamada M., Toba S, Yoshida Y, Haratani K, Mori D, Yano Y, Mimori-Kiyosue Y, Nakamura T, Sakata-Sogawa K, Tokunaga M, Ito K, Fushuki S, Setou M, Wynshaw-Boris A, Toyoshima YY, Hirotsune S
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Journal Title
EMBO J. 27
Pages: 2471-2483
Peer Reviewed
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