Elucidation of regulatory and repair mechanisms of brain lesion mediated by l ipid metabolism in glial cells.

2010 Fiscal Year Final Research Report

• Project/Area Number: 20500347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokushima Bunri University
• Principal Investigator: SONG Si-young 徳島文理大学, 神経科学研究所, 教授 (00399693)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Naohiro 国立長寿医療研究センター, 研究所再生再建医学研究部, 部長 (00208456)
• Project Period (FY): 2008 – 2010
• Keywords: グリア細胞

Research Abstract

We examined the expression changes of three kinds of lipid metabolism-related enzymes, lipidosin、lanosterol 14α-demethylase、and stearoyl-CoA desaturase, which are expressed in glial and neuronal cells in the nervous system, in the animal model of experimental demyelination, ischemia and neurodegeneration. We obtained findings that suggest involvements of these enzymes in the regulation of the development of brain lesions and the recovery processes from them such as remyelination, recovery from brain ischemia and early responses in neurodegeneration.

Research Products

• [Presentation] Expression of stearoyl-CoA desaturase isoforms in the brain and their changes in neuronal and glial cells during various kinds of brain injury (2010)
  • Author(s): Nakashima K., Fujii Y., Okazaki M., Kato C., Song S.-Y.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 20100902-04
• [Presentation] Expression of lanosterol 14-αdemethylase in the nervous system and its changes in the process of myelination and remyelination (2010)
  • Author(s): Song S.-Y., Okazaki M., Fujii Y., Kato C., Nakashima K.
  • Organizer: 7th Forum of European Neuroscience
  • Place of Presentation: Amsterdam, the Netherlands
  • Year and Date: 20100703-07
• [Presentation] Expression of Lanosterol 14-αDemethylase in the brain and its changes during myelination and remyelination (2009)
  • Author(s): Okazaki M., Nakashima K., Fujii Y., Kato C., Song S.-Y.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091208-12
• [Presentation] Expression of Stearoyl-CoA desaturase isoforms in the brain and their changes during the processes of experimental demyelination and remyelination (2009)
  • Author(s): Fujii Y., Nakashima K., Okazaki M., Chieko Kato., Song S-Y.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20091208-12
• [Remarks]
  • URL: http://kp.bunri-u.ac.jp/laboratory/neuroscience.html