2010 Fiscal Year Final Research Report
Elucidation of regulatory mechanism of AMPA-receptor's trafficking by visualization of its intracellular pool.
| Project/Area Number |
20500363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMAGUCHI Kazuhiko The Institute of Physical and Chemical Research, 運動学習制御研究チーム, 副チームリーダー (00191221)
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| Project Period (FY) |
2008 – 2010
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| Keywords | プルキンエ細胞 / シナプス可塑性 / 受容体トラフィッキング / グルタミン酸受容体 / スパイン / 長期抑圧 |
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| Research Abstract |
Long-term depression (LTD) of synaptic efficacy in the cerebellar Purkinje cell provides an underlying mechanism for motor learning. We analyzed distribution of intracellular pool of AMPA-receptors (AMPA-Rs) by means of double-expression of Green fluorescent protein (GFP) and Red fluorescent protein (mCherry)-tagged AMPA-Rs in cultured Purkinje cell. We found that LTD-stimulation caused translocation of intracellular pool of AMPA-Rs from the spine to the shaft of dendrite, but it caused no change in shape of the spine.
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[Journal Article] Dual involvement of G-substrate in motor learning revealed by gene deletion.2009
Author(s)
Endo S., Shuto F., Le D.T., Okamoto T., Ikeda T., Suzuki M., Kawahara S., Yanagihara D., Sato Y., Yamada K., Sakamoto T., Kirino Y., Hartell N.A., Yamaguchi K., Itohara S., Naim A., Greengarg P., Nagao S., Ito M.
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Journal Title
Proc.Natl.Acad.Sci.USA 106
Pages: 3525-3530
Peer Reviewed
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