2010 Fiscal Year Final Research Report
Development of ultrasound index to evaluate the effect of stress on cardiac function in small animals
Project/Area Number |
20500419
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical systems
|
Research Institution | Osaka University |
Principal Investigator |
ISHIKURA Fuminobu Osaka University, 大学院・医学系研究科, 准教授 (50303970)
|
Co-Investigator(Kenkyū-buntansha) |
ASANUMA Toshihiko 大阪大学, 大学院・医学系研究科, 特任研究員 (80379271)
|
Project Period (FY) |
2008 – 2010
|
Keywords | ストレス / 心機能 / 超音波法 / 小動物 / 性差 |
Research Abstract |
We measured the fractional area change (FAC) using SONOS5500 with s12 probe (frequency : 5-12MHz, frame rate : ≧120Hz) at the end of immobilization stress (IMO) and every 10min for 60 minutes in rats. FAC at 20 minutes after IMO significantly deceased and gradually recovered to 60 minutes after IMO. Acute administration of α β blocker or calcium antagonist could prevent a sudden drop of cardiac function and heart rate after acute stress like IMO. A α β blocker or calcium antagonist might have a very important role to prevent stress induced cardiac dysfunction.
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