2010 Fiscal Year Final Research Report
Elucidation of cartilage degeneration mechanism and rehabilitaton
| Project/Area Number |
20500449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
ORIGUCHI Tomoki Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (90295105)
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| Co-Investigator(Kenkyū-buntansha) |
OKITA MINORU 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50244091)
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| Project Period (FY) |
2008 – 2010
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| Keywords | リハビリテーション医学 |
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| Research Abstract |
We showed that immobilization induced thinning of the articular cartilage and cartilage degeneration. There were increased TUNNEL-posiyive chondrocytes and MMP expression. Vascular channels were appeared in the area between the calcified cartilage zone, in area with balanced expression of HIF-1alpha/VEGF and ChM-1. In addition, these changes were inhibited by continuous passive motion.
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