2010 Fiscal Year Final Research Report
Relative risk factors for obesity : A pilot study of genetic polymorphisms and physical characteristics in Japanese young (<BMI25) and elderly (>BMI25) women
| Project/Area Number |
20500620
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
FUKE Yoko Tokyo Metropolitan University, 大学院・人間健康科学研究科ヘルスプロモーションサイエンス学域, 教授 (20073562)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoko 首都大学東京, 大学院・人間健康科学研究科ヘルスプロモーションサイエンス学域, 助教 (00240531)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生活習慣病 |
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| Research Abstract |
This study aimed to investigate whether polymorphic variant related obesity are associated with physical characteristics on 40-60 years Japanese women (>BMI25) compared with healthy young women. The allele frequency of Pro12 of PPARγ2 were shown similar result as young women, but genotypic distribution of Trp/Arg on Arg64 of β_3-AR was lower, and G/G276 SNP of adiponectin gene was shown higher than young women. Young women who are normal weight (BMI19.9±1.60) estimating as the high risk of obesity on 3 candidate gene expression were 24%. To recognize own genetic factor participating in obesity at young time may have induced the changes in life-style to control body weight.
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