2010 Fiscal Year Final Research Report
Elucidation of mechanism of thrombus formation in older people during sporting activity and preventive measure thereof
| Project/Area Number |
20500623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nara Medical University |
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Principal Investigator |
ISHIZASHI Hiromichi Nara Medical University, 医学部, 准教授 (50260807)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Masanori 奈良県立医科大学, 医学部, 准教授 (60316081)
FUJIMURA Yoshihiro 奈良県立医科大学, 医学部, 教授 (80118033)
INOUE Yoshimitsu 大阪国際大学, 人間科学部, 教授 (70144566)
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| Project Period (FY) |
2008 – 2010
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| Keywords | スポーツ活動 / VWF / ADAMTS13 / 老化 / 脱水 |
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| Research Abstract |
Since there is a possibility of occurrence of imbalance between the thrombophilic action of VWF and the antithrombogenic action of ADAMTS13 due to aging, production of VWF in resting state and before and after sporting activity was investigated and compared between older peoples and young adults. The results indicated that older peoples had higher VWF antigen level in resting state as compared with young adults. In contrast, enzyme activity for decomposing ADAMTS13 activity was recognized as significantly lower in older peoples as compared with young adults. Based on this, lowering of the ADAMTS13 production amount itself due to aging was also presumed, though there is a possibility of lowering of the activity for decomposing VWF showing high level in resting state.
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