2010 Fiscal Year Final Research Report
Induction Mechanism of carcinogenesis in diabetic status and inhibitory effect of food components on the cancer.
| Project/Area Number |
20500711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
MASUDA Shuichi University of Shizuoka, 食品栄養科学部, 准教授 (40336657)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アクリルアミド / 糖尿病 / グリシダミド / 変異原性 / CYP2E1 / 緑茶 / ワサビ |
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| Research Abstract |
Genotocicities of acrylamide, which is a mutagen/carcinogen contained in foodstuffs, was increased in diabetic rats compared with those in normal rats. The activity of CYP2E1, known as a drug-metabolizing enzyme, in diabetic rats was stronger than that in normal rats. Therefore, AA was metabolic-activated to glycidamide by CYP2E1 in diabetic status. And green tea and Wasabi extracts showed the inhibitory effects against the genotocities of AA.
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