2010 Fiscal Year Final Research Report
Study of effects of alcohol intake on fat-soluble nutrients metabolisms and their mechanisms.
| Project/Area Number |
20500716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Nagasaki |
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Principal Investigator |
SURUGA Kazuhito University of Nagasaki, 看護栄養学部, 准教授 (70315852)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Noriaki 長崎県立大学, 看護栄養学部, 助教 (80516295)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルコール / 脂溶性栄養素 / ビタミンA / β-カロテン / 肝障害 / 炎症性サイトカイン / 機能性食品成分 |
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| Research Abstract |
As well as increased hepatic lipogenesis and decreased hepatic lipid oxidation, decreased level of hepatic lipid secretion-related gene expression may involve in the onset of chronic alcohol intake-induced hepatic steatosis in rats. In addition, the gene expression level involved in the conversion of beta-catotene into vitamin A in the small intestine decreased in the rats fed alcohol chronically, which may explain the alcohol-induced hypovitaminosis A.
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